889215-64-9Relevant articles and documents
Asymmetric synthesis of hexahydropyrrolo-isoquinolines by an organocatalytic three-component reaction
Fraile, Alberto,Scarpino Schietroma, Daniele M.,Albrecht, Anna,Davis, Rebecca L.,Jorgensen, Karl Anker
supporting information; body text, p. 2773 - 2776 (2012/04/04)
Merging three in one by a three-component organocatalytic asymmetric reaction of imines and α-bromoesters or ketones with α,β- unsaturated aldehydes provides optically active pyrrolo-isoquinolines-an important class of molecules in life science. The reaction proceeds with excellent enantioselectivity and a number of transformations of the products obtained demonstrated the potential of the new reaction. Copyright