889451-26-7

Basic information

• Product Name: 3-Iodo-4,7-diazaindole
• Synonyms: 3-Iodo-4,7-diazaindole;7-iodo-5H-pyrrolo[2,3-b]pyrazine
• CAS NO: 889451-26-7
• Molecular Formula: C₆H₄IN₃
• Molecular Weight: 245.02053
• Mol File: 889451-26-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Iodo-4,7-diazaindole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Iodo-4,7-diazaindole(889451-26-7)
• EPA Substance Registry System: 3-Iodo-4,7-diazaindole(889451-26-7)

Safety Data

• Hazardous Substances Data: 889451-26-7(Hazardous Substances Data)

Usage

General Description

3-Iodo-4,7-diazaindole is a chemical compound with the molecular formula C8H6IN3. It is a heterocyclic aromatic compound that contains both iodine and nitrogen atoms. 3-Iodo-4,7-diazaindole is often used as a building block in organic synthesis, particularly in the pharmaceutical industry for the production of drugs and drug intermediates. It has also been studied for its potential therapeutic properties, including its antibacterial and antifungal activities. Additionally, 3-Iodo-4,7-diazaindole has been investigated for its use in the development of novel materials and as a fluorescent probe in bioimaging applications. Overall, this compound has diverse applications and is of interest for its potential medicinal and technological uses.

InChI:InChI=1S/C6H4IN3/c7-4-3-10-6-5(4)8-1-2-9-6/h1-3H,(H,9,10)

Upstream product

• 4745-93-1 pyrrolo<2,3-b>pyrazine 

Downstream Products

• 1316228-57-5 7-(1-benzyl-1H-1,2,3-triazol-4-yl)-5H-pyrrolo-[2,3-b]pyrazine 
• 1316228-34-8 tert-butyl 7-(1-benzyltriazol-4-yl)pyrrolo[2,3-b]pyrazine-5-carboxylate 

Relevant articles and documents

INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF

The invention provides a class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence

The one-pot, three-component Sonogashira coupling-TMS-deprotection-CuAAC ("click") sequence is the key reaction for the rapid synthesis of triazolyl substituted N-Boc protected NH-heterocycles, such as indole, indazole, 4-, 5-, 6-, and 7-azaindoles, 4,7-diazaindole, 7-deazapurines, pyrrole, pyrazole, and imidazole. Subsequently, the protective group was readily removed to give the corresponding triazolyl derivatives of these tremendously important NH-heterocycles. All compounds have been tested in a broad panel of kinase assays. Several compounds, 8f, 8h, 8k, and 8l, have been shown to inhibit the kinase PDK1, a target with high oncology relevance, and thus they are promising lead structures for the development of more active derivatives. The X-ray structure analysis of compound 8f in complex with PDK1 has revealed the detailed binding mode of the molecule in the kinase. The Royal Society of Chemistry 2011.