88948-41-8

Usage

Structure

Ethyl ester derivative of a cyclic amino acid with a seven-membered ring structure

Physical state

Colorless liquid

Use in pharmaceutical industry

Building block for the synthesis of various drugs and active pharmaceutical ingredients

Potential therapeutic properties

Anticonvulsant, analgesic, treatment of neurological disorders, anti-inflammatory

Research status

Still under investigation, further research needed to fully understand its potential applications and mechanisms of action.

Upstream product

• 105-60-2 caprolactam 
• 539-74-2 Ethyl 3-bromopropionate 
• 140-88-5 ethyl acrylate 

Downstream Products

• 88948-38-3 N-Hydrazinocarbonylmethylcaprolactam 

Relevant academic research and scientific papers

Conjugate addition of amides to α,β-unsaturated esters by CsF-Si(OEt)4 system

The conjugate addition of amides to α,β-unsaturated esters proceeds efficiently with an equimolar amount of Si(OEt)4 and a catalytic amount of CsF to afford the corresponding N-substituted amides.

Rhodium(II) acetate catalyzed synthesis of cyclic enamides and enamines via β-hydride elimination

A series of cylic diazoamides and diazoamines were synthesized. Treatment of these cylic diazoamides and diazoamines with a catalytic amount of rhodium(II) acetate furnished the corresponding cyclic enamides and enamines, respectively. Interestingly, cyclic diazoamines produced stereoselectively Z-enamines.