68781-13-5

Basic information

• Product Name: 1-Aminocyclopropane-1-carboxylic acid hydrochloride
• Synonyms: ACPC HYDROCHLORIDE;1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID HYDROCHLORIDE;1-amino-1-cyclopropanecarboxylic acid hydrochlori;1-Aminocyclopropanecarboxylic acid hydrochloride;1-AMINO-1-CYCLOPROPANECARBOXYLIC ACID HYDROCHLORIDE, 97%;ACPC;1-AMINO-CYCLOPROPYL-1-METHANOL, HYDROCHLORIDE;1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID HCL
• CAS NO: 68781-13-5
• Molecular Formula: C₄H₇NO₂*ClH
• Molecular Weight: 137.56482
• Mol File: 68781-13-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 231 °C (dec.)(lit.)
• Boiling Point: 228.9 °C at 760 mmHg
• Flash Point: 92.2 °C
• Appearance: White to off-white/Crystalline Powder
• Vapor Pressure: 0.0256mmHg at 25°C
• Sensitive: Hygroscopic
• CAS DataBase Reference: 1-Aminocyclopropane-1-carboxylic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Aminocyclopropane-1-carboxylic acid hydrochloride(68781-13-5)
• EPA Substance Registry System: 1-Aminocyclopropane-1-carboxylic acid hydrochloride(68781-13-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• TSCA: No
• Hazardous Substances Data: 68781-13-5(Hazardous Substances Data)

Usage

Uses

1-Aminocyclopropanecarboxylic Acid Hydrochloride can be used as pesticides.

InChI:InChI=1/C4H7NO2.ClH/c5-4(1-2-4)3(6)7;/h1-2,5H2,(H,6,7);1H

Upstream product

• 109541-75-5 methyl 1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)cyclopropanecarboxylate 
• 6914-71-2 dimethyl 1,1-cyclopropanedicarboxylate 
• 6914-80-3 1-(aminocarbonyl)-1-cyclopropanecarboxylic acid methyl ester 
• 6914-74-5 1-aminocarbonylcyclopropanecarboxylic acid 
• 42303-43-5 1-Formylamino-cyclopropancarbonsaeure 
• 145618-70-8 1-(Benzhydrylidene-amino)-cyclopropanecarboxylic acid methyl ester 
• 127946-77-4 1-amino-1-cyclopropanecarbonitrile hydrochloride 
• 38409-69-7 methyl 1-(acetylamino)-1-cyclopropanecarboxylate 
• 6914-75-6 Cyclopropan-1-carbonsaeureethylester-1-carbonsaeureamid 

Downstream Products

• 148930-71-6 1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)cyclopropane-1-carboxylic acid 
• 88950-64-5 1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid 
• 72784-42-0 methyl 1-aminocyclopropane-1-carboxylate hydrochloride 
• 72784-47-5 ethyl 1-aminocyclopropane-1-carboxylate 
• 669066-98-2 1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid 
• 1192-20-7 2-aminobutyrolactone 
• 84677-06-5 (benzyloxycarbonylamino)cyclopropanecarboxylic acid 
• 22059-21-8 aminocyclopropane-1-carboxylic acid 

Relevant articles and documents

A Simple Synthesis of the Ripening Agent 1-Aminocyclopropane-1-carboxylic Acid

Conversion of chelated homoserine to 2-amino-4-bromobutyrate and treatment with aqueous base leads directly to chelated 1-aminocyclopropane-1-carboxylate.

PRODUCTION METHOD FOR 1-AMINO CYCLOPROPANE CARBOXYLIC ACID NONHYDRATE

1-Aminocyclopropanecarboxylic acid non-hydrate can be obtained by treating 1-aminocyclopropanecarboxylic acid hydrochloride with a tertiary amine in the presence of a C3-C4 alcohol and water, keeping the reaction mixture at 50° C. or below, collecting the precipitated crystal of 1-aminocyclopropanecarboxylic acid 0.5 hydrate by filtration, and heating the obtained crystal to 80 to 245° C.

NOVEL COMPOUND HAVING ABILITY TO INHIBIT 11B-HSD1 ENZYME OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof inhibiting 11β-HSD1 enzyme activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. Since the compound of the present invention selectively inhibits the activity of 11β-HSD1 (11β-Hydroxysteroid dehydrogenase type 1), the compound of the invention can be effectively used as a therapeutic agent for the treatment of diseases caused by the over-activation of 11β-HSD1 such as non-insulin dependent type II diabetes, insulin resistance, obesity, lipid disorder, metabolic syndrome, and other diseases or condition mediated by the excessive activity of glucocorticoid.