88962-26-9

Upstream product

• 63-91-2 L-phenylalanine 
• 540-51-2 2-bromoethanol 

Downstream Products

• 4530-37-4 N-t-butyloxycarbonylglycyl-L-phenylalanine 
• 76378-71-7 N-tritylglycyl-L-phenylalanine 
• 88962-36-1 N-benzyloxycarbonylglycyl-L-phenylalanine 2-bromoethyl ester 
• 88962-65-6 N-Benzyloxycarbonyl-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-L-seryl-L-phenylalanin-2-bromethylester 
• 88962-72-5 N-Benzyloxycarbonyl-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-L-seryl-L-leucyl-L-phenylalanin-2-bromethylester 
• 88962-71-4 N-Benzyloxycarbonyl-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-L-seryl-L-valyl-L-phenylalanin-2-bromethylester 
• 88962-54-3 N-Benzyloxycarbonyl-L-seryl-L-leucyl-L-phenylalanin-2-bromethylester 
• 88962-31-6 N-Benzyloxycarbonyl-L-seryl-L-phenylalanin-2-bromethylester 
• 123872-99-1 N-t-butyloxycarbonylglycyl-L-phenylalanine 2-bromoethyl ester 
• 88962-33-8 N-Benzyloxycarbonyl-L-isoleucyl-L-phenylalanin-2-bromethylester 
• 88962-73-6 N-Benzyloxycarbonyl-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-L-seryl-L-phenylalanyl-L-valin-2-bromethylester 
• 88962-74-7 N-Benzyloxycarbonyl-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-L-seryl-L-phenylalanin-2-iodethylester 
• 88962-80-5 C₅₄H₄₈N₂O₁₅ 
• 88962-42-9 N-Benzyloxycarbonyl-L-isoleucyl-L-phenylalanin-2-iodethylester 

Relevant academic research and scientific papers

NEW APPROACH TO THE USE OF 2-BROMOETHYL ESTERS IN PEPTIDE SYNTHESIS

The synthesis of six fully protected dipeptides 2-bromoethyl esters and a new method for the removal of the C-protection by the action of the sulphide anion, at room temperature, are described.

Glycopeptide Synthesis: Selective C-terminal Deblocking and Peptide Chain Elongation of Glucosylserine Derivatives

Benzyloxycarbonyl-(Z-)serine 2-bromoethyl ester (3b) reacts with 2,3,4,6-tetra-O-benzoyl-α-D-glucopyranosyl bromide (14) to give the glucosylserine ester 15.After conversion into the corresponding 2-iodoethyl ester 23 the carboxylic group is deblocked selectively by reductive elimination using zinc.In this procedure the Z and the carbohydrate protective functions as well as the sensitive O-glycoside bond remain unaffected.The glycosylserine 24 is condensed with amino acid 2-bromoethyl esters 2 to form protected glycodipeptide 2-bromoethyl esters 18 which are extended to give glycotripeptide esters 25 after selective carboxyl deblocking.Whereas protected serine dipeptides 5 are glycosylated with 14 to form the conjugates 18, the glycosylation of the serine tripeptides 10 was not successful.