88980-10-3Relevant academic research and scientific papers
Biomimetic approach to potential benzodiazepine receptor agonists and antagonists
Guzman,Cain,Larscheid,Hagen,Cook,Schweri,Skolnick,Paul
, p. 564 - 570 (2007/10/02)
Several β-carbolines, isoquinolines, imidazopyridines, and canthin-6-ones prepared in biomimetic fashion were tested for their ability to bind the benzodiazepine receptor. Methyl isoquinoline-3-carboxylate, methyl 6,7-dimethoxyisoquinoline-3-carboxylate,
BIOMIMETIC APPROACH TO POTENTIAL BENZODIAZEPINE AGONISTS AND ANTAGONISTS
Cain, Michael,Guzman, Fil,Cook, James M.,Rice, Kenner C.,Skolnick, Phil
, p. 1003 - 1007 (2007/10/02)
A series of heterocycles have been prepared via the Pictet-Spengler reaction and several of these (β-carbolines 2-8, isoquinoline 11a and imidazopyridine derivative 16b) have been found to bind to the benzodiazepine receptor in vitro with moderate to high
