88982-82-5

Basic information

• Product Name: 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID
• Synonyms: 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID;4-BROMO-2-THIAZOLE CARBOXYLIC ACID;4-BROMO-THIAZOLE-2-CARBOXYLIC ACID;4-BROMO-1,3-THIAZOLE-2-CA...;2-Thiazolecarboxylicacid,4-broMo
• CAS NO: 88982-82-5
• Molecular Formula: C₄H₂BrNO₂S
• Molecular Weight: 208.03
• Mol File: 88982-82-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 372.5±34.0 °C(Predicted)
• Appearance: /
• Density: 2.062±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.53±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID(88982-82-5)
• EPA Substance Registry System: 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID(88982-82-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 88982-82-5(Hazardous Substances Data)

Usage

General Description

4-Bromo-1,3-thiazole-2-carboxylic Acid is a chemical compound with the molecular formula C5H3BrNO2S. It is a heterocyclic organic compound that contains a bromine atom, a thiazole ring, and a carboxylic acid group. 4-BROMO-1,3-THIAZOLE-2-CARBOXYLIC ACID is commonly used in the synthesis of pharmaceuticals and agrochemicals, specifically in the construction of various biologically active molecules. It is also utilized in the field of organic chemistry for the creation of diverse organic compounds. The compound has been the subject of research for its potential biological and pharmacological properties.

InChI:InChI=1S/C4H2BrNO2S/c5-2-1-9-3(6-2)4(7)8/h1H,(H,7,8)

Upstream product

• 124-38-9 carbon dioxide 
• 1613393-51-3 (3aR,5S)-5-methyl-3,3a,4,5-tetrahydro-7H-pyrano[3,4-c][1 ,2]oxazole 
• 4175-77-3 2,4-dibromo-1,3-thiazole 
• 167366-05-4 4-bromo-1,3-thiazole-2-carbaldehyde 
• 959755-96-5 ethyl 4-bromothiazole-2-carboxylate 

Downstream Products

• 912639-91-9 4-bromo-1,3-thiazole-2-carboxamide 
• 886366-96-7 4-(4-fluorophenyl)thiazole-2-carboxylic acid 
• 886367-05-1 4-(4-(trifluoromethoxy)phenyl)thiazole-2-carboxylic acid 
• 1180496-00-7 N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-bromothiazole-2-carboxamide 
• 1025468-06-7 methyl 4-bromo-1,3-thiazole-2-carboxylate 
• 141761-77-5 4-bromo-2-(trifluoromethyl)thiazole 

Relevant articles and documents

FORMAMIDE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

The present invention relates to a formamide compound, a preparation method therefor and an application thereof. The structure of the compound is shown in formula (I), and the definition of each variable in the formula is as provided in the description. The compound is capable of inhibiting the activity of ASK1 kinase. The compound of the present invention may be used in the treatment/prevention of diseases associated with ASK1 kinase, such as inflammatory diseases, metabolic diseases, autoimmune diseases, cardiovascular diseases, neurodegenerative diseases, cancers and other diseases.

AMINO HETEROCYCLIC COMPOUNDS AND USES THEREOF

The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory, and autoimmune diseases and cancers.

Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists

We described here the synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as potential mGluR5 antagonists. We found that a series of thiazole derivatives 6 showed better inhibitory activity against mGluR5. Compounds 6bc and 6bj have been identified as potent antagonists (IC50 = 274 and 159 nM) showing excellent in vitro stability profile. Molecular docking study using the crystal structure of mGluR5 revealed that our compounds 6bc and 6bj fit the allosteric binding site of mavoglurant well.