167366-05-4

Basic information

• Product Name: 4-BROMO-2-FORMYLTHIAZOLE
• Synonyms: 4-BROMO-2-FORMYLTHIAZOLE;4-Bromo-2-formylthiazole, 4-Bromothiazole-2-carbaldehyde;4-Bromo-1,3-thiazole-2-carboxaldehyde;2-Formyl-4-bromo-1,3-thiazole;4-broMo-1,3-thiazole-2-carbaldehyde;4-BroMothiazole-2-carboxaldehyde;2-Thiazolecarboxaldehyde,4-broMo-;4-Bromothiazole-2-carboxaldehyde 96%
• CAS NO: 167366-05-4
• Molecular Formula: C₄H₂BrNOS
• Molecular Weight: 192.03
• EINECS: 1533716-785-6
• Product Categories: Organohalides;Thiazole
• Mol File: 167366-05-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 66-70℃
• Boiling Point: 288℃
• Flash Point: 128℃
• Appearance: /
• Density: 1.920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.33±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-2-FORMYLTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-FORMYLTHIAZOLE(167366-05-4)
• EPA Substance Registry System: 4-BROMO-2-FORMYLTHIAZOLE(167366-05-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 167366-05-4(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-formylthiazole is a chemical compound with the molecular formula C5H3BrNOS. It is a thiazole derivative, which is a five-membered aromatic heterocycle containing both sulfur and nitrogen atoms. 4-Bromo-2-formylthiazole is commonly used as a reagent in organic synthesis, especially in the preparation of pharmaceuticals and agrochemicals. It is also known for its use as an intermediate in the synthesis of various biologically active compounds. Additionally, it has been studied for its potential antimicrobial and antibacterial properties, making it a subject of interest in the development of new drug candidates. Overall, 4-Bromo-2-formylthiazole is a versatile chemical with various applications in organic chemistry and drug discovery.

Upstream product

• 4175-77-3 2,4-dibromo-1,3-thiazole 
• 68-12-2 N,N-dimethyl-formamide 
• 4394-85-8 4-morpholinecarboxaldehyde 

Downstream Products

• 912639-91-9 4-bromo-1,3-thiazole-2-carboxamide 
• 88982-82-5 4-bromo-1,3-thiazole-2-carboxylic acid 
• 1255940-28-3 (4-bromo-1,3-thiazol-2-yl)(3-methoxyphenyl)methanol 
• 383142-08-3 4-(2,4-dimethoxyphenyl)thiazole-2-carboxaldehyde 
• 383141-30-8 4-(5-bromo-2-methoxyphenyl)thiazole-2-carboxaldehyde 
• 383140-16-7 4-(5-chloro-2-methoxyphenyl)thiazole-2-carboxaldehyde 
• 383144-24-9 4-(2,5-dimethoxyphenyl)thiazole-2-carboxaldehyde 
• 204513-31-5 (4-bromo-1,3-thiazol-2-yl)methanol 

Relevant articles and documents

Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure-Activity Relationships and Facilitates Mechanism of Action Studies

Colibactin is a genotoxic metabolite produced by commensal-pathogenic members of the human microbiome that possess the clb (aka pks) biosynthetic gene cluster. clb+ bacteria induce tumorigenesis in models of intestinal inflammation and have been causally

Chemoenzymatic synthesis of highly enantiomerically enriched secondary alcohols with a thiazolic core

Stereoselective preparative enzymatic acylation and hydrolysis/methanolysis of various C-substituted rac-thiazol-2-yl-methanols were achieved for the preparation of enantiopure or enantiomerically enriched, naturally occurring 2-hydroxymethylthiazoles. The absolute configurations of the resulting secondary alcohols were determined by a detailed 1H NMR study of Mosher's derivatives.

FLUORINATED AMINOTRIAZOLE DERIVATIVES

The invention relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.