889855-42-9

Basic information

• Product Name: 2-Propenoic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-3-phenyl-, (2E)-
• CAS NO: 889855-42-9
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Mol File: 889855-42-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-3-phenyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-3-phenyl-, (2E)-(889855-42-9)
• EPA Substance Registry System: 2-Propenoic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-3-phenyl-, (2E)-(889855-42-9)

Safety Data

• Hazardous Substances Data: 889855-42-9(Hazardous Substances Data)

Upstream product

• 889855-43-0 methyl (E)-2-[(tert-butoxycarbonylamino)methyl]-3-phenylacrylate 
• 910329-40-7 ethyl 3-tert-butoxycarbonylamino-2-diethoxyphosphoryl-3-propionate 
• 100-52-7 benzaldehyde 
• 124957-63-7 methyl (E)-2-(azidomethyl)-3-phenyl-2-propenoate 
• 103669-71-2 (Z)-methyl 2-(bromomethyl)-3-phenylacrylate 
• 18020-59-2 methyl 3-hydroxy-2-methylidene-3-phenylpropionate 
• 124957-67-1 2-aminomethyl-3-phenylacrylic acid methyl ester 

Downstream Products

• 26250-90-8 (S)-2-[(tert-butoxycarbonylamino)methyl]-3-phenylpropanoic acid 
• 26250-90-8 (R)-3-tert-butyloxycarbonyl-β²-homophenylalanine 

Relevant articles and documents

Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity

The TWIK-related K+ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs, suggesting that activation of TREK-1 could result in pain inhibition. Here, we report the synthesis of a series of substituted acrylic acids (1-54) based on our previous work with caffeate esters. The analogues were evaluated for their ability to modulate TREK-1 channel by electrophysiology and for their in vivo antinociceptive activity (acetic acid-induced writhing and hot plate assays), leading to the identification of a series of novel molecules able to activate TREK-1 and displaying potent antinociceptive activity in vivo. Furyl analogue 36 is the most promising of the series.

SEVEN-MEMBERED RING COMPOUND, PRODUCTION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF

A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.