477585-43-6

Basic information

• Product Name: AMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER
• Synonyms: AMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER;(2S, 2R)-GLY-4-PYRANOYL-OME;METHYL AMINO(TETRAHYDRO-2H-PYRAN-4-YL)ACETATE;METHYL AMINO-(4-TETRAHYDROPYRANYL) ACETATE;methyl aminotetrahydropyr...;Methyl aMinotetrahydropyran-4-ylacetate;2H-Pyran-4-acetic acid, a-aMinotetrahydro-, Methyl ester;Methyl 2-aMino-2-(tetrahydro-2H-pyran-4-yl)acetate hydrochloride
• CAS NO: 477585-43-6
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 173.21
• Mol File: 477585-43-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: AMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: AMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER(477585-43-6)
• EPA Substance Registry System: AMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER(477585-43-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 477585-43-6(Hazardous Substances Data)

Usage

General Description

Amino-(tetrahydro-pyran-4-yl)-acetic acid methyl ester is a chemical compound that contains an amino group and a carboxylic acid functional group. It is also known as a tertiary amine and is commonly used in organic synthesis as a chiral building block. AMINO-(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID METHYL ESTER is often used in the preparation of pharmaceuticals and agrochemicals. It is a colorless liquid with a slightly sweet odor, and it is soluble in organic solvents. Amino-(tetrahydro-pyran-4-yl)-acetic acid methyl ester has a range of potential applications in the fields of medicine and agriculture due to its unique chemical structure and reactivity.

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 477584-90-0 methyl 2-(((benzyloxy)carbonyl)amino)-2-(dihydro-2H-pyran-4(3H)-ylidene)acetate 

Downstream Products

• 950192-18-4 racemic Cbz-pyranylglycine methyl ester 
• 889949-63-7 2-amino-2-(tetrahydro-2H-pyran-4-yl)ethanol 
• 1035279-38-9 C₃₃H₄₃N₅O₅ 
• 1035278-84-2 C₂₈H₃₅N₅O₃ 
• 871261-11-9 (R)-N-Cbz-pyranylglycine methyl ester 
• 894789-28-7 (S)-N-Cbz-pyranyl glycine methyl ester 
• 368866-32-4 (S)-pyranylglycine methyl ester 
• 1188366-14-4 methyl 2-((tert-butoxy)carbonyl)amino-2-(tetrahydro-2H-pyran-4-yl)acetate 
• 182287-49-6 2-((tert-butoxy)carbonyl)amino-2-(tetrahydro-2H-pyran-4-yl)acetic acid 

Relevant articles and documents

Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation

The discovery of natural specialized pro-resolving mediators and their corresponding receptors, such as formyl peptide receptor 2 (FPR2), indicated that resolution of inflammation (RoI) is an active process which could be harnessed for innovative approaches to tame pathologies with underlying chronic inflammation. In this work, homology modelling, molecular docking and pharmacophore studies were deployed to assist the rationalization of the structure-activity relationships of known FPR2 agonists. The developed pharmacophore hypothesis was then used in parallel with the homology model for the design of novel ligand structures and in virtual screening. In the first round of optimization compound 8, with a cyclopentane core, was chosen as the most promising agonist (β-arrestin recruitment EC50 = 20 nM and calcium mobilization EC50 = 740 nM). In a human neutrophil static adhesion assay, compound 8 decreased the number of adherent neutrophils in a concentration dependent manner. Further investigation led to the more rigid cycloleucines (compound 22 and 24) with improved ADME profiles and maintaining FPR2 activity. Overall, we identified novel cyclopentane urea FPR2 agonists with promising ADMET profiles and the ability to suppress the inflammatory process by inhibiting the neutrophil adhesion cascade, which indicates their anti-inflammatory and pro-resolving properties.

AMIDE COMPOUND

The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

AZAINDOLE INHIBITORS OF IAP

The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: I wherein X1, X2, Y, Z1, Z2, Z3, Z4, R1, R2, R3, R3', R4, R4', R5, R6, R6' and R9 are as described herein.