890027-41-5

Upstream product

• 1444378-51-1 2-methyl-2-(3-phenyl-2-propenyl)malonic acid monomethyl ester 
• 609-02-9 methyl-malonic acid dimethylester 
• 4392-24-9 3-bromo-1-phenyl-1-propenyl bromide 
• 189884-53-5 2-methyl-2-(3-phenyl-2-propenyl)malonic acid dimethyl ester 

Downstream Products

• 890027-31-3 (-)-tert-butyl-[(2R,4S,5S,6R,7S)-7-methoxymethoxymethyl-4,7-dimethyl-6-vinyl-1-oxaspiro[4.4]non-2-ylmethoxy]diphenylsilane 
• 890028-20-3 (+)-tert-butyl-[(2R,4S,5R,6R,7S)-7-methoxymethoxymethyl-4,7-dimethyl-6-vinyl-1-oxaspiro[4.4]non-2-ylmethoxy]diphenylsilane 
• 890028-22-5 (-)-tert-butyl-[(2R,4S,5S,6S,7S)-7-methoxymethoxymethyl-4,7-dimethyl-6-vinyl-1-oxaspiro[4.4]non-2-ylmethoxy]diphenylsilane 
• 1344673-83-1 2-{(2R,4S,5S,6R,7S)-2-tert-butyldiphenylsilyloxymethyl-7-methoxymethoxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl}ethyl pivalate 
• 1344673-84-2 2-[(2R,4S,5S,6R,7S)-2-tert-butyldiphenylsilyloxymethyl-7-hydroxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl pivalate 
• 1344673-75-1 2-[(2R,4S,5S,6R,7S)-2-tert-butyldiphenylsilyloxymethyl-7-formyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl pivalate 
• 1344673-77-3 2-[(2R,4S,5S,6R,7S)-7-[(R)-((1S,2S,3S)-2-tert-butyldimethylsilyloxymethyl-3-tert-butyldiphenylsilyloxy-5-oxocyclopentyl)(hydroxy)methyl]-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl 2,2-dimethylpropanoate 
• 1344673-74-0 2-[(2R,4S,5S,6R,7R)-7-[(E)-((2S,3S)-2-tert-butyldimethylsilyloxymethyl-3-tert-butyldiphenylsilyloxy-5-oxocyclopentylidene)methyl]-2-tert-butyldiphenylsilyloxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethyl 2,2-dimethylpropanoate 
• 890027-54-0 (2R)-4-(1-ethoxyethoxy)-2-((methoxymethoxy)methyl)-2-methylbutanal 
• 890027-35-7 (3S,5R)-5-(tert-butyldiphenylsilanyloxymethyl)-2-[(E)-(3S)-3-methoxymethoxymethyl-3-methyl-6-trimethylsilanyl-hex-4-enyl]-3-methyltetrahydrofuran-2-ol 
• 890027-95-9 (-)-2-[(2R,4S,5R,6R,7S)-2-(tert-butyldiphenylsilanyloxymethyl)-7-methoxymethoxymethyl-4,7-dimethyl-1-oxaspiro[4.4]non-6-yl]ethanol 
• 890028-07-6 (-)-2-[(2R,4S,5S,6S,7S)-2-(tert-butyldiphenylsilanyloxymethyl)-7-methoxymethoxymethyl-1-oxaspiro[4.4]non-6-yl]ethanol 
• 890027-63-1 2-[(2R,4S,5S,6R,7S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-7-[(methoxymethoxy)methyl]-4,7-dimethyl-1-oxaspiro[4.4]nonan-6-yl]ethan-1-ol 

Relevant academic research and scientific papers

Enantioselective total synthesis of (+)-ophiobolin A

The enantioselective total synthesis of (+)-ophiobolin A is described. This total synthesis features the construction of the spiro CD ring of (+)-ophiobolin A through a stereoselective intramolecular Hosomi-Sakurai cyclization reaction, the joining of the

Research on the pig liver esterase (PLE)-catalyzed kinetic resolution of half-esters derived from prochiral diesters

The pig liver esterase (PLE)-catalyzed kinetic resolution of half-esters derived from prochiral diesters is described. Generally, the PLE-catalyzed enantioselective hydrolysis of prochiral diesters affords the corresponding half-esters in high yield, beca

Synthetic studies on (+)-ophiobolin A: Asymmetric synthesis of the spirocyclic CD-ring moiety

Asymmetric synthesis of the spirocyclic CD-ring moiety of (+)-ophiobolin A is described. Fragment A, which was prepared via pig liver esterase (PLE)-mediated kinetic resolution, and fragment B, which was prepared via diastereoselective allylation and subs