890091-73-3Relevant academic research and scientific papers
Catalyst-free synthesis of 3-sulfone nitrile from sulfonyl hydrazides and acrylonitrile in water
Li, Wei,Gao, Lingfeng,Zhuge, Wenyun,Sun, Xu,Zheng, Gengxiu
, p. 7819 - 7823 (2017/10/06)
A novel catalyst-free sulfonation reaction for synthesizing 3-sulfone nitrile compounds from sulfonyl hydrazides and acrylonitriles in water, without any metal catalyst, ligand or organic solvent, was demonstrated. This catalyst-free protocol provides a new synthetic method for the construction of 3-sulfone nitrile compounds with excellent yields. The D2O experiment adequately proved that the catalyst-free sulfonation reaction occurs via a Michael addition mechanism and that the hydrogen of 3-sulfone nitrile comes from water.
Method for synthesizing 3-sulfonyl nitrile compound
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Paragraph 0013, (2017/04/03)
The invention discloses a method for synthesizing a 3-sulfonyl nitrile compound. The method includes the steps of using substituted sulfonhydrazide and an acrylonitrile compound as raw materials for a reaction in water by heating to obtain the 3-sulfonyl nitrile compound, and after the reaction, obtaining the 3-sulfonyl nitrile compound with a purity of 95% or above by simple separation. Compared with other synthetic methods, the method is simpler in reaction step, more environmentally friendly in synthesis and higher in yield. Important nitrile pharmaceutical chemical intermediates are directly synthesized by one step, and a novel method is provided for synthesizing the sulfonyl-substituted nitrile compound for the field of chemical synthesis.
