89043-73-2Relevant academic research and scientific papers
Methotrexate Analogues. 19. Replacement of the Glutamate Side Chain in Classical Antifolates by L-Homocysteic Acid and L-Cysteic Acid: Effect on Enzyme Inhibition and Antitumor Activity
Rosowsky, Andre,Forsch, Ronald A.,Freisheim, James H.,Moran, Richard G.,Wick, Michael
, p. 600 - 604 (2007/10/02)
Methotrexate (MTX) and aminopterin (AMT) analogues containing L-homocysteic acid or L-cysteic acid in place of L-glutamic acid were synthesized and tested as inhibitors of dihydrofolate reductase from L1210 cells and folyl polyglutamate synthetase from mo
