89043-76-5

Upstream product

• 36093-85-3 4-amino>benzoic acid 
• 54-62-6 aminopterin 
• 89043-75-4 4-amino-4-deoxy-N¹⁰-formylpteroic acid 
• 89043-78-7 L-homocysteic acid methyl ester hydrochloride 
• 96193-18-9 2-Amino-4-sulfo-butyric acid methyl ester; hydrochloride 

Downstream Products

• 96193-19-0 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-4-sulfo-butyric acid 
• 89043-73-2 N-(4-amino-1-deoxypteroyl)-L-homocysteic acid 

Relevant academic research and scientific papers

Methotrexate Analogues. 19. Replacement of the Glutamate Side Chain in Classical Antifolates by L-Homocysteic Acid and L-Cysteic Acid: Effect on Enzyme Inhibition and Antitumor Activity

Methotrexate (MTX) and aminopterin (AMT) analogues containing L-homocysteic acid or L-cysteic acid in place of L-glutamic acid were synthesized and tested as inhibitors of dihydrofolate reductase from L1210 cells and folyl polyglutamate synthetase from mo