89069-78-3Relevant academic research and scientific papers
Eco-friendly Synthesis of 3-(Aryl)-2,6-diphenylpyrimidin-4(3H)-ones, Ethyl-1-(aryl)-1,6-dihydro-2-(aryl)-6-oxopyrimidine-4-carboxylates and 6-(4-Arylphenyl)-2-isopropylpyrimidin-4(3H)-one
Anantoju, Kishore Kumar,Eppakayala, Laxminarayana,Maringanti, Thirumala Chary
, p. 845 - 850 (2019/03/07)
In present communication, we report the synthesis of pyrimidin-4(3H)-one derivatives by microwave irradiation in good yields and less reaction time. All titled compounds were characterized by IR, NMR and Mass spectral analyses.
Synthesis and Biological Activity of 2,6-disubstituted 3-Aryl-4(3H)-pyrimidones as Potential CNS Agents
Gupta, K. A.,Saxena, Anil K.,Jain, Padam C.,Dua, P. R.,Prasad, C. R.,Anand, Nitya
, p. 789 - 794 (2007/10/02)
The reaction of N-arylamidines (III) with appropriate 2-alkynoic ester gives 2,6-disubstituted 3-aryl-4(3H)-pyrimidones (IV) in one step except in the reaction of N-(2-trifluoromethylphenyl/biphenyl)-S-methylisothiourea with ethyl propiolate, where the required pyrimidones (IVa17/IVa20) along with the adduct (Va/Vb) have been isolated; these adducts on cyclisation yield the corresponding pyrimidinones (IVa17/IVa20). 2,3,6-Triphenyl-4(3H)-pyrimidone (IVh1) on treatment with P2S5 furnishes the corresponding thione (VI).Some of these compounds have shown significant central muscle relaxant, hypnotic, anticonvulsant, CNS depressant, antiinflammatory and diuretic activities.
