890848-64-3Relevant academic research and scientific papers
Synthesis and pharmacological investigation of 2-(4-dimethylaminophenyl)-3, 5-disubstituted thiazolidin-4-ones as anticonvulsants
Senthilraja, Manavalan,Alagarsamy, Veerachamy
, p. 827 - 833,7 (2012)
A new series of 2-(4-dimethylaminophenyl)-3-substituted thiazolidin-4-one-5-yl-acetyl acetamides/benzamides were synthesized by the nucleophilic substitution of 3-substituted-2-(4-dimethylaminophenyl)- thiazolidin-4-one-5-yl-acetylchloride with acetamide and benzamide. The starting material 3-substituted-2-(4-dimethylaminophenyl)-thiazolidin-4-one-5-yl- acetylchloride was synthesized from 3-substituted-2-(4-dimethylaminophenyl)- thiazolidin-4-one-5-yl-acetic acid, which in turn was prepared by one-pot reaction of amino component, p-dimethylamino benzaldehyde and mercapto succinic acid. The title compounds were investigated for their anticonvulsant activities; among the test compounds, compound 2-(4-dimethylaminophenyl)-3-phenylamino- thiazolidine-4-one-5-yl-acetylbenzamide (14) emerged as the most active compound of the series and as moderately more potent than the reference standard diazepam. Copyright
Synthesis and pharmacological investigation of 2-(4-dimethylaminophenyl)-3, 5-disubstituted thiazolidin-4-ones as anticonvulsants
Senthilraja, Manavalan,Alagarsamy, Veerachamy
, p. 827 - 833 (2013/01/15)
A new series of 2-(4-dimethylaminophenyl)-3-substituted thiazolidin-4-one-5-yl-acetyl acetamides/benzamides were synthesized by the nucleophilic substitution of 3-substituted-2-(4-dimethylaminophenyl)- thiazolidin-4-one-5-yl-acetylchloride with acetamide
