89100-25-4Relevant academic research and scientific papers
Electrophilic aromatic aroylation with CF3-bearing arenecarboxylic acid derivatives: Reaction behavior and acidic mediator dependence
Akiko, Okamoto,Katsuya, Maeyama,Hideaki, Oike,Noriyuki, Yonezawa
, p. 2701 - 2715 (2008/02/12)
Triflic acid (TfOH) has been proven to be effective as a tolerant acidic mediator in electrophilic aromatic aroylation with CF3-bearing aroyl chlorides. The TfOH-mediated aroylation of fluorobenzene proceeds with high selectivity to give CF3-bearing aryl fluorophenyl ketones in good yields, which are hardly obtained with the aid of AlCl3 or direct condensation reagents. Copyright Taylor & Francis Group, LLC.
