952111-57-8

Upstream product

• 89100-25-4 4-(4-trifluoromethylbenzoyl)benzoic acid 
• 108-88-3 toluene 
• 34328-30-8 4-trifluoromethyl-4′-methylbenzophenone 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 

Downstream Products

• 1000813-25-1 1,1-dimethylethyl (2S)-2-methyl-4-[(4-{methyl[(4-{[4-(trifluoromethyl)phenyl]carbonyl}phenyl)carbonyl]amino}phenyl)methyl]-1-piperazinecarboxylate 

Relevant academic research and scientific papers

Electrophilic aromatic aroylation with CF3-bearing arenecarboxylic acid derivatives: Reaction behavior and acidic mediator dependence

Triflic acid (TfOH) has been proven to be effective as a tolerant acidic mediator in electrophilic aromatic aroylation with CF3-bearing aroyl chlorides. The TfOH-mediated aroylation of fluorobenzene proceeds with high selectivity to give CF3-bearing aryl fluorophenyl ketones in good yields, which are hardly obtained with the aid of AlCl3 or direct condensation reagents. Copyright Taylor & Francis Group, LLC.

PIPERAZINYL DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES

The invention relates to compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.