891844-69-2Relevant articles and documents
Discovery of novel and long acting muscarinic acetylcholine receptor antagonists
Jin, Jian,Wang, Yonghui,Shi, Dongchuan,Wang, Feng,Davis, Roderick S.,Jin, Qi,Fu, Wei,Foley, James J.,Webb, Edward F.,Dehaas, Chris J.,Berlanga, Manuela,Burman, Miriam,Sarau, Henry M.,Morrow, Dwight M.,Rao, Parvathi,Kallal, Lorena A.,Moore, Michael L.,Rivero, Ralph A.,Palovich, Michael,Salmon, Michael,Belmonte, Kristen E.,Busch-Petersen, Jakob
, p. 4866 - 4869 (2008)
High throughput screening and subsequent optimization led to the discovery of novel quaternary ammonium salts as highly potent muscarinic acetylcholine receptor antagonists with excellent selectivity. Compounds 8a, 13a, and 13b showed excellent inhibitory