Discovery of novel and long acting muscarinic acetylcholine receptor antagonists

DOI: 10.1021/jm800634k

Source and publish data:

Journal of Medicinal Chemistry p. 4866 - 4869 (2008)

Update date:2022-08-04

Topics:

Authors:

Jin, Jian

Wang, Yonghui

Shi, Dongchuan

Wang, Feng

Davis, Roderick S.

Jin, Qi Jin, Qi

Fu, Wei Fu, Wei

Foley, James J.

Webb, Edward F.

Dehaas, Chris J.

Berlanga, Manuela

Burman, Miriam

Sarau, Henry M.

Morrow, Dwight M.

Rao, Parvathi

Kallal, Lorena A.

Moore, Michael L.

Rivero, Ralph A.

Palovich, Michael

Salmon, Michael

Belmonte, Kristen E.

Busch-Petersen, Jakob

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Article abstract of DOI:10.1021/jm800634k

High throughput screening and subsequent optimization led to the discovery of novel quaternary ammonium salts as highly potent muscarinic acetylcholine receptor antagonists with excellent selectivity. Compounds 8a, 13a, and 13b showed excellent inhibitory

Full text of DOI:10.1021/jm800634k

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