89201-08-1Relevant articles and documents
Synthesis and biological evaluation of new 1,4-benzothiazine derivatives as potential COX-2 inhibitors
Meenakshi, Maniarasu,Antojenifer, Panneerselvam,Karthikeyan, Muthusamy,Prahalathan, Chidambaram,Srinivasan, Kannupal
, p. 351 - 358 (2021/11/03)
A series of new 2H-benzo[1,4]thiazine derivatives were synthesized from aroylmethylidene malonates and o-aminothiophenols by condensation/cyclization methodology in order to evaluate their COX-2 inhibitory activity. In-silico studies indicated that among
Cu(OAc)2-Promoted Oxidative Cross-Dehydrogenative Coupling Reaction of α-Acylmethyl Malonates with Indole Derivatives to Access 3-Functionalized Indoles and Polycyclic Indoles
Zhou, Li-Jin,Wang, Kun,Guan, Hong-Rong,Zheng, An-Qi,Yang, Hai-Tao,Miao, Chun-Bao
, p. 7925 - 7938 (2020/07/25)
A Cu(OAc)2-promoted oxidative cross-dehydrogenative coupling reaction of α-acylmethyl malonates with indole derivatives was developed. In the case of indoles, the regioselective coupling products were formed through a sequential dehydrogenation-addition-dehydrogenation process. When a second nucleophilic center was located in the 2-position of indoles, further successive nucleophilic cyclization occurred to give polycyclic indole derivatives. The Cu(OAc)2 was proved to act as not only an oxidant but also a catalyst.
Organocatalytic enantioselective conjugate addition of pyrazolin-5-ones to arylomethylidene malonates
Sharma, Arun,Sharma, Vivek,Chimni, Swapandeep Singh
, p. 9514 - 9523 (2019/11/14)
An efficient asymmetric organocatalytic conjugate addition reaction of pyrazolin-5-ones with arylomethylidene malonates has been successfully developed by employing bifunctional Cinchona derived thiourea organocatalysts. The protocol provides straightforward access to pyrazole substituted scaffolds in good yields with high stereocontrol.
Regioselective oxidative ring-opening of cyclopropenyl carboxylates by visible light photoredox catalysis
Ye, Qianwen,Ye, Hongqiang,Cheng, Dongping,Li, Xiaonian,Xu, Xiaoliang
, p. 2546 - 2549 (2018/05/28)
Catalyzed by Ir(dFCF3ppy)2(dtbbpy)PF6, several aroyl methylidenemalonates were synthesized in good to excellent yields via visible light photoredox-catalyzed the oxidative ring-opening of cyclopropenyl carboxylate derivatives. The possible mechanism of oxidative quenching cycle was proposed.
Synthesis method of benzoyl methylene malonate derivatives
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Paragraph 0025; 0026; 0027; 0028, (2017/08/27)
The invention discloses a synthesis method of benzoyl methylene malonate derivatives as shown in a formula II. Diester-based cyclopropane compound shown in the formula I is used as a raw material, under the action of a silver catalyst, Selectfluor is taken as an oxidizing agent, and in an acetonitrile solvent, the reaction materials are stirred at 70-110 DEG C and allowed to react for 8-24 hours, and after the reaction, the reaction solution is subjected to post-treatment to prepare the benzoyl methylene malonate derivatives shown in the formula II. The synthesis method disclosed by the invention has the advantages of cheap and easily available raw materials, simple process, simplicity and convenience in operation, and being environment-friendly, high in yield, good in functional group universality and the like.
Method for synthesizing benzoyl methylene malonic ester compound
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Paragraph 0025; 0026; 0027; 0028, (2017/07/01)
The invention discloses a method for synthesizing a benzoyl methylene malonic ester compound of a formula II as shown in the description. The method comprises the following steps: by taking a diester cyclopropane compound of a formula I as shown in the description as a raw material, under the action of an iron catalyst, by taking Selectfluor as an oxidant, in the presence of an acetonitrile solvent, performing stirring reaction for 8-16 hours at 70-90 DEG C, and after the reaction is completed, performing aftertreatment on a reaction liquid to obtain the benzoyl methylene malonic ester compound of the formula II as shown in the description. The method disclosed by the invention has the advantages that the raw materials are low in price and easily accessible, the process is simple, the operation is simple and convenient, environmental friendliness is achieved, the yield is high, and the functional group universality is good.
Synthesis of 2,3-disubstituted thiophenes from 2-aryl-3-nitro-cyclopropane-1,1-dicarboxylates and 1,4-dithiane-2,5-diol
Selvi, Thangavel,Vanmathi, Govindhraj,Srinivasan, Kannupal
, p. 49326 - 49329 (2015/06/16)
A two-step synthesis of 2,3-disubstituted thiophenes from trans-2-aryl-3-nitrocyclopropane-1,1-dicarboxylates and 1,4-dithiane-2,5-diol is described. The nitrocyclopropane dicarboxylates when treated with boron trifluoride etherate formed aroylmethylidene
Boron Trifluoride-Promoted Indium(III) Triflate-Catalyzed Sequential One-Pot Synthesis of (1,2-Diaryl-2-oxoethyl)malonates from trans-2-Aryl-3-nitrocyclopropane-1,1-dicarboxylates and Activated Arenes
Selvi, Thangavel,Srinivasan, Kannupal
, p. 2111 - 2118 (2015/06/25)
A sequential one-pot synthesis of Michael adducts of aroylmethylidenemalonates with activated aromatics is described. The method involves treatment of trans-2-aryl-3-nitro-cyclopropane-1,1-dicarboxylates with boron trifluoride etherate to form aroylmethyl
Boron trifluoride mediated ring-opening reactions of trans -2-aryl-3-nitro-cyclopropane-1,1-dicarboxylates. Synthesis of aroylmethylidene malonates as potential building blocks for heterocycles
Selvi, Thangavel,Srinivasan, Kannupal
, p. 3653 - 3658 (2014/05/06)
trans-2-Aryl-3-nitro-cyclopropane-1,1-dicarboxylates, upon treatment with BF3·OEt2, undergo ring-opening rearrangement and the Nef reaction to give aroylmethylidene malonates. The products are found to be potential precursors for het
