892142-87-9Relevant academic research and scientific papers
Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors
Ducray, Richard,Ballard, Peter,Barlaam, Bernard C.,Hickinson, Mark D.,Kettle, Jason G.,Ogilvie, Donald J.,Trigwell, Catherine B.
, p. 959 - 962 (2008)
Novel 4-anilino-1H-pyrazolo[3,4-d]pyrimidines have been synthesized and evaluated in vitro for erbB2 and EGFR kinase inhibition. A representative compound displaying oral bioavailability in rat and dog illustrates the potential of this series to provide o
PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS
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Page/Page column 95, (2010/11/08)
The invention concerns compounds of the formula (I) wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.
