Bioorganic and Medicinal Chemistry Letters p. 959 - 962 (2008)
Update date:2022-08-04
Topics:
Ducray, Richard
Ballard, Peter
Barlaam, Bernard C.
Hickinson, Mark D.
Kettle, Jason G.
Ogilvie, Donald J.
Trigwell, Catherine B.
Novel 4-anilino-1H-pyrazolo[3,4-d]pyrimidines have been synthesized and evaluated in vitro for erbB2 and EGFR kinase inhibition. A representative compound displaying oral bioavailability in rat and dog illustrates the potential of this series to provide o
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