89281-44-7Relevant academic research and scientific papers
Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer
Scott, David A.,Aquila, Brian M.,Bebernitz, Geraldine A.,Cook, Donald J.,Dakin, Les A.,Deegan, Tracy L.,Hattersley, Maureen M.,Ioannidis, Stephanos,Lyne, Paul D.,Omer, Charles A.,Ye, Minwei,Zheng, XiaoLan
scheme or table, p. 4794 - 4797 (2009/05/30)
The bisamide class of kinase inhibitors was identified as being active against CSF-1R. The synthesis and SAR of pyridyl and thiazolyl bisamides are reported, along with the pharmacokinetic properties and in vivo activity of selected examples.
CHEMICAL COMPOUNDS
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Page/Page column 48, (2008/06/13)
The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
Imidazopyrazines as protein kinase inhibitors
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Page/Page column 171, (2010/11/27)
In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.
Positive allosteric modulators of the nicotinic acetylcholine receptor
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Page 33, (2010/02/05)
The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.
