892873-11-9 Usage
Uses
Used in Pharmaceutical Research and Development:
2,3-Pyridinediamine, N3-[[5-(1H-indol-6-yl)-2-(phenylmethoxy)phenyl]methyl]is used as a candidate for drug design and synthesis due to its complex molecular structure and the presence of various functional groups that may interact with biological targets.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2,3-Pyridinediamine, N3-[[5-(1H-indol-6-yl)-2-(phenylmethoxy)phenyl]methyl]is utilized for the development of new pharmaceutical agents, potentially targeting a range of diseases and conditions. Its unique structure may allow for the creation of novel drugs with improved efficacy and selectivity.
Used in Drug Discovery:
2,3-Pyridinediamine, N3-[[5-(1H-indol-6-yl)-2-(phenylmethoxy)phenyl]methyl]is employed in drug discovery processes to identify new lead compounds or optimize existing ones. Its structural features may offer opportunities for the development of drugs with enhanced pharmacokinetic and pharmacodynamic profiles.
Used in Biochemical Research:
2,3-Pyridinediamine, N3-[[5-(1H-indol-6-yl)-2-(phenylmethoxy)phenyl]methyl]is also used in biochemical research to study the interactions between small molecules and biological macromolecules, such as proteins and nucleic acids. Understanding these interactions can provide insights into the molecular mechanisms of diseases and aid in the design of targeted therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 892873-11-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,2,8,7 and 3 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 892873-11:
(8*8)+(7*9)+(6*2)+(5*8)+(4*7)+(3*3)+(2*1)+(1*1)=219
219 % 10 = 9
So 892873-11-9 is a valid CAS Registry Number.
892873-11-9Relevant academic research and scientific papers
Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of β-secretase
Congreve, Miles,Aharony, David,Albert, Jeffrey,Callaghan, Owen,Campbell, James,Carr, Robin A. E.,Chessari, Gianni,Cowan, Suzanna,Edwards, Philip D.,Frederickson, Martyn,McMenamin, Rachel,Murray, Christopher W.,Patel, Sahil,Wallis, Nicola
, p. 1124 - 1132 (2007/10/03)
Fragment-based lead discovery has been successfully applied to the aspartyl protease enzyme β-secretase (BACE-1). Fragment hits that contained an aminopyridine motif binding to the two catalytic aspartic acid residues in the active site of the enzyme were the chemical starting points. Structure-based design approaches have led to identification of low micromolar lead compounds that retain these interactions and additionally occupy adjacent hydrophobic pockets of the active site. These leads form two subseries, for which compounds 4 (IC50 = 25 μM) and 6c (IC50 = 24 μM) are representative. In the latter series, further optimization has led to 8a (IC50 = 690 nM).
SUBSTITUTED AMINOPYRIDINES AND USES THEREOF
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Page/Page column 135; 138, (2010/11/08)
This invention relates to novel compounds having the structural formula (I) and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
