89373-87-5

Upstream product

• 21262-23-7 2-(4-chloro-anilino)-thiazol-4-one 
• 100-52-7 benzaldehyde 
• 75861-69-7 trans-3-Phenylpropenoyl isothiocyanate 
• 3696-23-9 N-(4-chlorophenyl)thiourea 
• 21262-23-7 2-(4-chlorophenylimino)-1,3-thiazolidin-4-one 
• 3289-75-6 2-chloro-N-(4-chlorophenyl)acetamide 
• 106-47-8 4-chloro-aniline 
• 89373-78-4 N-(4-chlorophenyl)-N'-(3-phenylpropenoyl)thiourea 

Downstream Products

• 847021-06-1 2-(2-{2-[(E)-4-Chloro-phenylimino]-4-oxo-5-[1-phenyl-meth-(Z)-ylidene]-thiazolidin-3-yl}-ethoxy)-isoindole-1,3-dione 
• 847021-33-4 2-(4-chloro-phenylimino)-7-phenyl-2,3-dihydro-thiazolo[4,5-d]pyrimidin-5-ol 
• 847021-24-3 2-(4-{2-[(E)-4-Chloro-phenylimino]-4-oxo-5-[1-phenyl-meth-(Z)-ylidene]-thiazolidin-3-yl}-butoxy)-isoindole-1,3-dione 
• 847021-15-2 2-(3-{2-[(E)-4-Chloro-phenylimino]-4-oxo-5-[1-phenyl-meth-(Z)-ylidene]-thiazolidin-3-yl}-propoxy)-isoindole-1,3-dione 

Relevant academic research and scientific papers

Novel 2-(substituted phenyl Imino)-5-benzylidene-4-thiazolidinones as possible non-ulcerogenic tri-action drug candidates: synthesis, characterization, biological evaluation And docking studies

The present research was aimed at the synthesis and screening of 35 novel 2-(substituted phenyl imino)-5-benzylidene-4-thiazolidinones having different substitutions at imino phenyl and arylidene groups. The title compounds were synthesized by Knoevenagel

Effect of chloro and fluoro groups on the antimicrobial activity of 2,5-disubstituted 4-thiazolidinones: A comparative study

The article reports the synthesis of a series comprising of twenty-one 2,5-disubstituted-4-thiazolidinone derivatives, bearing 3-chloro-4-fluorophenyl imino, 4-chlorophenyl imino and 3-chlorophenyl imino groups at position-2 and substituted arylidene grou

NEW COMBINATION FOR USE IN THE TREATMENT OF CANCER

There is provided combination products comprising (a) a compound of formula (I): wherein X, Y, T, W, A1, A2 R1, R5 and R6 have meanings given in the description, and (b) tamoxifen or an aromatase inhi

Synthesis and biological evaluation of 7-N-(n-alkoxyphthalimido)-2hydroxy- 4-aryl-6-aryliminothiazolidino [2,3-b] pyrimidines and related compounds

Substituted aryl thioureas 1a-c react with chloroacetic acid in the presence of anhydrous sodium acetate to furnish 2-aryliminothiazolidin-4-ones 2a-c. Condensation of ω-bromoalkoxyphthalimides 3a-c with 2a-c give the corresponding alkoxyphthalimide derivatives of 2-aryliminothiazolidin-4-ones 4a-i. These on condensation with araldehydes 5a-c yield 3-N-(alkoxyphthalimido)- 5-arylidene-2-aryliminothiazolidin-4-ones 7a-a′. In an alternative route 5a-c react with 2a-c to give 6a-i, which could be cyclised with urea in the presence of sodium acetate to yield the corresponding thiazolidinopyrimidine 8a-i. 7a-a′ are also prepared from 6a-i with 3a-c, which give final compound 9a-a′ on cyclisation. Alternatively, 8a-i when condensed with 3a-c also furnish the compounds 9a-a′. Evaluation of antimalarial and antibacterial activity is also reported.

BROMINE OXIDATION OF N-(3 OR 4-SUBSTITUTED PHENYL)-N'-3-PHENYLPROPENOYLTHIOUREAS

Bromine oxidation of N-(3- or 4-substituted phenyl)-N'-3-phenylpropenoylthioureas in chloroform afforded either derivatives of benzylidenethiazoline or benzothiazole depending on the structure of aniline residue.The structure of the title products was proved by elementar analysis,IR, 1H NMR and 13C NMR spectral data.