893739-89-4

Basic information

• Product Name: 4-CYCLOPROPYL-2-FLUOROANILINE
• Synonyms: AKOS BAR-1302;4-CYCLOPROPYL-2-FLUOROANILINE;4-Cyclopropyl-2-fluorophenylamine
• CAS NO: 893739-89-4
• Molecular Formula: C₉H₁₀FN
• Molecular Weight: 151.18
• Mol File: 893739-89-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CYCLOPROPYL-2-FLUOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYCLOPROPYL-2-FLUOROANILINE(893739-89-4)
• EPA Substance Registry System: 4-CYCLOPROPYL-2-FLUOROANILINE(893739-89-4)

Safety Data

• Hazardous Substances Data: 893739-89-4(Hazardous Substances Data)

Usage

Uses

4-Cyclopropyl-2-fluorophenylamine is used in of arylamide derivatives as RAF/MEK complex stabilizers and/or MEK inhibitors and antitumor agents.

Upstream product

• 367-24-8 4-bromo-2-fluoroaniline 
• 411235-57-9 cyclopropylboronic acid 
• 932700-92-0 4-cyclopropyl-2-fluoro-1-nitrobenzene 
• 394-41-2 3-fluoro-4-nitrophenol 
• 256935-94-1 trifluoromethanesulfonic acid 3-fluoro-4-nitrophenyl ester 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 1168091-05-1 5-(2-fluoro-4-cyclopropylphenylamino)-imidazo[1,5-a]pyridine-6-carboxylic acid methyl ester 
• 1168102-38-2 8-(4-cyclopropyl-2-fluorophenylamino)-imidazo[1,5-a]pyridine-7-carboxylic acid methyl ester 
• 1030383-32-4 4-cyclopropyl-2-fluoro-1-iodobenzene 
• 1203662-87-6 7-(4-cyclopropyl-2-fluoro-phenylamino)-benzo[d]isothiazole-6-carboxylic acid 

Relevant articles and documents

OXEPAN-2-YL-PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE

Oxepan-2-yl pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for in

PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE

Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS

The invention relates to bicyclic heterocycles of formulae I and II with anti-cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.