893746-80-0

Upstream product

• 348-52-7 1-Fluoro-2-iodobenzene 
• 2028-63-9 but-3-yn-2-ol 

Downstream Products

• 726202-39-7 chloro-acetic acid 3-(2-fluoro-phenyl)-1-methyl-prop-2-ynyl ester 
• 726202-40-0 carbonic acid 3-(2-fluoro-phenyl)-1-methyl-prop-2-ynyl ester phenyl ester 
• 1386903-32-7 4-(2-fluorophenyl)but-3-yn-2-one 

Relevant academic research and scientific papers

Nickel-Catalyzed Asymmetric Propargylic Amination of Propargylic Carbonates Bearing an Internal Alkyne Group

We have achieved the nickel-catalyzed asymmetric propargylic amination of propargylic carbonates bearing an internal alkyne group. A wide variety of propargylic carbonates and N-methylaniline derivatives were tolerated under the reaction conditions, providing the corresponding chiral propargylic amines in up to 97% yield with up to 97% ee.

B(C6F5)3-catalyzed allylation of propargyl acetates with allylsilanes.

[reaction: see text] An efficient method for the B(C(6)F(5))(3)-catalyzed allylation of secondary propargylic alcohol derivatives with allylsilanes has been developed. This method allows for the facile synthesis of a variety of 1,5-enynes in good to high yields with a number of functionalities, such as nitro, chloro, ester, and boronic ester, being tolerated under the reaction conditions.