893767-87-8

Upstream product

• 616-75-1 2-benzylmalonic acid 
• 15781-74-5 bis(2,4,6-trichlorophenyl)-2-benzylmalonate 
• 94-09-7 p-aminoethylbenzoate 

Downstream Products

• 1599529-20-0 ethyl 3-benzyl-2,4-dibromoquinoline-6-carboxylate 
• 1599529-23-3 (3-benzyl-2,4-dimethylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone 
• 1599529-22-2 3-benzyl-N-methoxy-N,2,4-trimethylquinoline-6-carboxamide 
• 1599529-21-1 ethyl 3-benzyl-2,4-dimethylquinoline-6-carboxylate 
• 1599529-19-7 (3-benzyl-2,4-dichloroquinolin-6-yl)(4-chlorophenyl)methanone 
• 1599529-18-6 ethyl 3-benzyl-2,4-dichloroquinoline-6-carboxylate 

Relevant academic research and scientific papers

METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.