89380-13-2

Upstream product

• 1722-10-7 3-chloro-6-methoxypyridazine 
• 864780-69-8 6-chloro-3-methoxypyridazine-4-carbaldehyde 
• 89466-48-8 (6-chloro-3-methoxypyridazin-4-yl)methanol 
• 89581-65-7 6-chloro-3-methoxypyridazine-4-carboxylic acid 
• 1591827-16-5 methyl 6-chloro-3-methoxy-pyridazine-4-carboxylate 
• 286946-24-5 methyl 3,6-dichloropyridazine-4-carboxylate 
• 51149-08-7 3,6-dichloropyridazin-4-carboxylic acid 

Downstream Products

• 1591827-79-0 3-chloro-5-((1-((6-chloro-3-methoxypyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile 

Relevant academic research and scientific papers

CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS

The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.

PRODRUGS OF HIV REVERSE TRANSCRIPTASE INHIBITORS

Compounds of Formula I are described: wherein R1 and R2 are defined herein. The compounds of Formula I are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV, and the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.