1591827-16-5

Basic information

• Product Name: methyl 6-chloro-3-methoxy-pyridazine-4-carboxylate
• CAS NO: 1591827-16-5
• Molecular Weight: 202.597
• Mol File: 1591827-16-5.mol

Chemical Properties

• CAS DataBase Reference: methyl 6-chloro-3-methoxy-pyridazine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 6-chloro-3-methoxy-pyridazine-4-carboxylate(1591827-16-5)
• EPA Substance Registry System: methyl 6-chloro-3-methoxy-pyridazine-4-carboxylate(1591827-16-5)

Safety Data

• Hazardous Substances Data: 1591827-16-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 286946-24-5 methyl 3,6-dichloropyridazine-4-carboxylate 
• 124-41-4 sodium methylate 
• 51149-08-7 3,6-dichloropyridazin-4-carboxylic acid 

Downstream Products

• 89380-13-2 6-chloro-4-(chloromethyl)-3-methoxypyridazine 
• 1591827-79-0 3-chloro-5-((1-((6-chloro-3-methoxypyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile 
• 1591827-87-0 3-chloro-5-((1-((3-methoxy-6-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)pyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile 
• 1591827-88-1 3-chloro-5-((1-((6-(hydroxymethyl)-3-methoxypyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile 
• 1591827-89-2 3-chloro-5-((1-((6-formyl-3-methoxypyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile 
• 1591827-90-5 3-chloro-5-((1-((6-(difluoromethyl)-3-methoxypyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile 
• 1591826-32-2 3-chloro-5-((1-((6-(difluoromethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile 
• 1591823-90-3 3-chloro-5-((1-((5-(2-hydroxypropan-2-yl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile 

Relevant articles and documents

MODULATORS OF THR-β AND METHODS OF USE THEREOF

Disclosed herein are compounds of Formula (I) or a pharmaceutically acceptable salt, prodrug, amide or ester thereof, where i) TL is a moiety of Formula IlIa, lIIb, IlIa, IIIb, IIIc, or IIId; ii) CE is a moiety of Formula IV; iii) HD is a moiety of Formula V or VI; where the substituents are as defined herein. Disclosed are also pharmaceutical compositions comprising the above compounds, and methods of treating disease by administering or contact a patient with one or more of the above compounds.

PRODRUGS OF HIV REVERSE TRANSCRIPTASE INHIBITORS

Compounds of Formula I are described: wherein R1 and R2 are defined herein. The compounds of Formula I are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV, and the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.