894071-04-6

Basic information

• Product Name: 5-amino-3-methyl-3H-imidazole-4-carboxylic acid (4-chloro-phenyl)-amide
• CAS NO: 894071-04-6
• Molecular Weight: 250.688
• Mol File: 894071-04-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-amino-3-methyl-3H-imidazole-4-carboxylic acid (4-chloro-phenyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-3-methyl-3H-imidazole-4-carboxylic acid (4-chloro-phenyl)-amide(894071-04-6)
• EPA Substance Registry System: 5-amino-3-methyl-3H-imidazole-4-carboxylic acid (4-chloro-phenyl)-amide(894071-04-6)

Safety Data

• Hazardous Substances Data: 894071-04-6(Hazardous Substances Data)

Upstream product

• 54828-05-6 1-methyl-4-nitro-1H-imidazole-5-carboxylic acid 
• 61982-14-7 1-methyl-4-nitroimidazolyl-5-carboxylic acid chloroanhydride 
• 40648-96-2 1-methyl-4-nitro-1H-imidazole-5-carbonitrile 
• 894071-01-3 3-methyl-5-nitro-3H-imidazole-4-carboxylic acid (4-chloro-phenyl)-amide 

Relevant articles and documents

ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2

We have developed a series of novel potent ortho-substituted azole derivatives active against kinases VEGFR-1 and VEGFR-2. Both specific and dual ATP-competitive inhibitors of VEGFR-2 were identified. Kinase activity and selectivity could be controlled by varying the arylamido substituents at the azole ring. The most specific molecule (17) displayed >10-fold selectivity for VEGFR-2 over VEGFR-1. Compound activities in enzymatic and cell-based assays were in the range of activities for reported clinical and development candidates (IC50 30 × 10-5 cm/min) is indicative of their potential for intestinal absorption upon oral administration.