894085-99-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(1,3,5-triphenyl-1H-pyrazol-4-yl)-1H-pyrazole is used as a building block for the synthesis of various organic molecules. Its application in the pharmaceutical industry is primarily as a precursor for the development of new drugs and medications, thanks to its versatile chemical structure that can be modified to create a range of therapeutic compounds.
Used in Research and Drug Development:
In the realm of research and drug development, 1-(1,3,5-triphenyl-1H-pyrazol-4-yl)-1H-pyrazole serves as an important compound for creating novel organic molecules. Its unique structure allows scientists to explore new avenues in the synthesis of potential therapeutic agents, contributing to the advancement of medical treatments.
Used in Materials Science and Organic Chemistry:
1-(1,3,5-triphenyl-1H-pyrazol-4-yl)-1H-pyrazole may also have uses in the field of materials science and organic chemistry. Its potential applications include the creation of novel materials and compounds, which could have a wide range of uses from industrial to consumer products, depending on the specific properties of the synthesized materials.

Upstream product

• 728-84-7 2-bromo-1,3-diphenylpropane-1,3-dione 
• 894085-98-4 1,3-diphenyl-2-pyrazol-1-yl-propane-1,3-dione 
• 100-63-0 phenylhydrazine 
• 120-46-7 1,3-diphenylpropanedione 

Downstream Products

• 1239478-87-5 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole 
• 894086-00-1 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole 

Relevant academic research and scientific papers

A general and efficient catalyst for palladium-catalyzed C-O coupling reactions of aryl halides with primary alcohols

An efficient procedure for palladium-catalyzed coupling reactions of (hetero)aryl bromides and chlorides with primary aliphatic alcohols has been developed. Key to the success is the synthesis and exploitation of the novel bulky di-1-adamantyl-substituted bipyrazolylphosphine ligand L6. Reaction of aryl halides including activated, nonactivated, and (hetero)aryl bromides as well as aryl chlorides with primary alcohols gave the corresponding alkyl aryl ethers in high yield. Noteworthy, functionalizations of primary alcohols in the presence of secondary and tertiary alcohols proceed with excellent regioselectivity.

Streamlined synthesis of the bippyphos family of ligands and cross-coupling applications

We describe the efficient preparation of Bippyphos, 1. The key precursor to Bippyphos, 5, was prepared via a one-pot bromination of diketone 2 followed by alkylation with pyrazole and condensation with phenylhydrazine. Lithiation of 5 and trapping with ditert-butylchlorophosphine afforded Bippyphos, 1. Using this approach we have prepared several derivatives of Bippyphos to probe the structure and activity relationships of this family of phosphine ligands. We also demonstrate the utility of these ligands in Pdcatalyzed amination reactions and other cross-coupling reactions.

Development of nonproprietary phosphine ligands for the Pd-catalyzed amination reaction

A new family of pyrazole and bi-pyrazole phosphine ligands are reported that perform efficiently in the Pd-catalyzed amination reaction. Of the ligands screened, ligand 1 emerged as the most compatible for couplings involving both primary and secondary am