894430-39-8

Upstream product

• 67-56-1 methanol 
• 72261-44-0 1,2-O-isopropylidene-3-O-benzyl-4-C-(hydroxymethyl)-β-L-threo-pento-1,4-furanose 
• 410076-92-5 3-O-benzyl-5-O-(methanesulfonyl)-4-C-[[(methanesulfonyl)oxy]methyl]-1,2-O-isopropylidene-β-L-threo-pentofuranose 

Downstream Products

• 894430-48-9 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-5-(9'-fluorenylmethoxycarbonyl)-7-hydroxy-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-46-7 (1S,3R,4S,7R)-7-benzyloxy-1-(4,4'-dimethoxytrityloxymethyl)-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 866611-96-3 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-44-5 (1S,3R,4S,7R)-7-benzyloxy-1-hydroxymethyl-3-(thymin-1-yl)-5-trifluoroacetyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-43-4 (1S,3R,4S,7R)-7-benzyloxy-1-methanesulfonoxymethyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-45-6 (1S,3R,4S,7R)-7-benzyloxy-1-hydroxymethyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-41-2 1-O-acetyl-2-azido-3-O-benzyl-2-deoxy-5-O-methanesulfonyl-4-C-methanesulfonoxymethyl-α,β-L-erythro-pentofuranose 
• 894430-40-1 methyl 2-azido-3-O-benzyl-2-deoxy-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-α,β-L-erythro-pentofuranoside 

Relevant academic research and scientific papers

Synthesis and hybridization studies of 2′-amino-α-L-LNA and tetracyclic "locked LNA"

A convergent route to a new class of locked nucleic acids, i.e., 2′-amino-α-L-LNA, has been developed. The optimized synthetic route to the corresponding phosphoramidite building block of thymine proceeds in 4% overall yield over 15 steps from the startin

Synthesis of a 2′-amino-α-L-LNA-T phosphoramidite

A convergent route to 2′-amino-α-L-LNA-T phosphoramidite building block 16 has been developed. Key steps include 1) introduction of a C2-azido group prior to nucleobase-coupling, 2) tandem Staudinger and intramolecular nucleophilic substitution reaction,