89459-31-4Relevant academic research and scientific papers
Potential Antitumor Agents. 50. In Vivo Solid-Tumor Activity of Derivatives of N-acridine-4-carboxamide
Atwell, Graham J.,Rewcastle, Gordon W.,Baguley, Bruce C.,Denny, William A.
, p. 664 - 669 (2007/10/02)
The synthesis, physicochemical properties, and antitumor activity of a series of N-acridine-4-carboxamides are reported.The compounds bind to DNA by intercalation, but exist under physiological conditions as monocations due to the w
Acridinecarboxamide compounds
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, (2008/06/13)
4-Carboxamidoacridine compounds represented by the general formula (I), STR1 where R1 represents H, CH3 or NHR3, where R3 is H, COCH3, SO2 CH3, COPh, SO2 Ph or lower alkyl optionally substituted with hydroxyl and/or amino functions; R2 represents H or up to two of the groups CH3, OCH3, halogen, CF3, NO2, NH2, NHCOCH3, and NHCOOCH3 placed at positions 1-3 or 5-8; Y represents C(NH)NH2, NHC(NH)NH2, or NR4 R5, where each of R4 and R5 is H or lower alkyl optionally substituted with hydroxyl and/or amino functions; and x is from 2 to 6, and the acid addition salts thereof, possess antibacterial and antitumor properties.
