894802-98-3

Basic information

• Product Name: 7-amino-4-pentafluorophenylmethyl-1H-quinolin-2-one
• Synonyms: 7-amino-4-pentafluorophenylmethyl-1H-quinolin-2-one
• CAS NO: 894802-98-3
• Molecular Weight: 340.252
• Mol File: 894802-98-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-amino-4-pentafluorophenylmethyl-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-amino-4-pentafluorophenylmethyl-1H-quinolin-2-one(894802-98-3)
• EPA Substance Registry System: 7-amino-4-pentafluorophenylmethyl-1H-quinolin-2-one(894802-98-3)

Safety Data

• Hazardous Substances Data: 894802-98-3(Hazardous Substances Data)

Upstream product

• 653-21-4 2,3,4,5,6-pentafluorophenylacetic acid 
• 832-72-4 2,3,4,5,6-pentafluorophenylacetyl chloride 

Relevant articles and documents

Modulation of luminescence intensity of lanthanide complexes by photoinduced electron transfer and its application to a long-lived protease probe

Luminescent lanthanide complexes (Tb3+, Eu3+, etc.) have excellent properties for biological applications, including extraordinarily long lifetimes and large Stokes shifts. However, there have been few reports of lanthanide-based functional probes, because of the difficulty in designing suitable complexes with a luminescent on/off switch. Here, we have synthesized a series of complexes which consist of three moieties: a lanthanide chelate, an antenna, and a luminescence off/on switch. The antenna is an aromatic ring which absorbs light and transmits its energy to the metal, and the switch is a benzene derivative with a different HOMO level. If the HOMO level is higher than a certain threshold, the complex emits no luminescence at all, which indicates that the lanthanide luminescence can be modulated by photoinduced electron transfer (PeT) from the switch to the sensitizer. This approach to control lanthanide luminescence makes possible the rational design of functional lanthanide complexes, in which the luminescence property is altered by a biological reaction. To exemplify the utility of our approach to the design of lanthanide complexes with a switch, we have developed a novel protease probe, which undergoes a significant change in luminescence intensity upon enzymatic cleavage of the substrate peptide. This probe, combined with time-resolved measurements, was confirmed in model experiments to be useful for the screening of inhibitors, as well as for clinical diagnosis.