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832-72-4

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832-72-4 Usage

General Description

(2,3,4,5,6-pentafluorophenyl)acetyl chloride is a chemical compound with the formula C8H2ClF5O. It is a derivative of acetyl chloride and is characterized by the presence of a pentafluorophenyl group. (2,3,4,5,6-pentafluorophenyl)acetyl chloride is commonly used as an intermediate in organic synthesis, particularly in the production of various pharmaceuticals and agrochemicals. It is also used in the manufacturing of specialty chemicals and dyes. (2,3,4,5,6-pentafluorophenyl)acetyl chloride is a highly reactive compound that must be handled with caution due to its potential to cause irritation and injury.

Check Digit Verification of cas no

The CAS Registry Mumber 832-72-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,3 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 832-72:
(5*8)+(4*3)+(3*2)+(2*7)+(1*2)=74
74 % 10 = 4
So 832-72-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H2ClF5O/c9-3(15)1-2-4(10)6(12)8(14)7(13)5(2)11/h1H2

832-72-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2,3,4,5,6-pentafluorophenyl)acetyl chloride

1.2 Other means of identification

Product number -
Other names Pentafluorphenylacetylchlorid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:832-72-4 SDS

832-72-4Relevant articles and documents

Phosphonic acid analogs of fluorophenylalanines as inhibitors of human and porcine aminopeptidases N: Validation of the importance of the substitution of the aromatic ring

Dziuk, B?a?ej,Kafarski, Pawe?,Pirat, Jean-Luc,Talma, Micha?,Wanat, Weronika

, (2020/05/04)

A library of phosphonic acid analogs of phenylalanine substituted with fluorine, chlorine and trifluoromethyl moieties on the aromatic ring was synthesized and evaluated for inhibitory activity against human (hAPN) and porcine (pAPN) aminopeptidases. Fluorogenic screening indicated that these analogs are micromolar or submicromolar inhibitors, both enzymes being more active against hAPN. In order to better understand the mode of the action of the most active compounds, molecular modeling was used. It confirmed that aminophosphonic portion of the enzyme is bound nearly identically in the case of all the studied compounds, whereas the difference in activity results from the placement of aromatic side chain of an inhibitor. Interestingly, both enantiomers of the individual compounds are usually bound quite similarly.

Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C–F bonds as steroid sulfatase inhibitors

Da?ko, Mateusz,Rachon, Janusz,Mas?yk, Maciej,Kubiński, Konrad,Demkowicz, Sebastian

, p. 156 - 161 (2017/06/19)

Steroid sulfatase (STS) is responsible for the hydrolysis of biologically inactive sulfated steroids into their active un-sulfated forms and promotes the growth of various hormone-dependent cancers (e.g., breast cancer). Therefore, the STS enzyme is a promising therapeutic target for the treatment of steroid-sensitive cancers. Herein, we report the synthesis and biological evaluation of sulfamate analogs as potential STS inhibitors based on N-acylated tyramines that contain C–F bonds. The inhibitory effects of the analogs were tested using STS isolated from human placenta. Of the analogs tested, 4-(2-perfluoroundecanoylaminoethyl)-phenyl sulfamate, 5r, demonstrated the greatest inhibitory effect, with an IC50 value of 2.18?μm (IC50 value of 2.13?μm for coumarin-7-O-sulfamate was used as a reference). These findings were supported by the results our computational analyses performed using molecular docking techniques.

Redox-responsive conformational alteration of aromatic amides bearing N-quinonyl system

Okamoto, Iwao,Takahashi, Yusuke,Sawamura, Mika,Matsumura, Mio,Masu, Hyuma,Katagiri, Kosuke,Azumaya, Isao,Nishino, Masanori,Kohama, Yukari,Morita, Nobuyoshi,Tamura, Osamu,Kagechika, Hiroyuki,Tanatani, Aya

experimental part, p. 5346 - 5355 (2012/09/07)

Redox-induced conformational alteration of N-aryl-N-phenylamides, in which the N-aryl group consists of a hydroquinone-p-quinone system, was examined. The reduced form bearing a dihydroxyphenyl or dimethoxyphenyl group exists mainly in the E-form, whereas the oxidized form bearing a N-benzoquinone moiety takes the Z-form both in the crystal and in solution. This redox-induced conformational alteration is associated with a marked change in optical properties. This system appears to have suitable properties for use in external redox stimulus-responsive functional switching.

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