89489-76-9Relevant academic research and scientific papers
A New Chemoenzymatic Approach to the Synthesis of Penems
Altamura, Maria,Cesti, Pietro,Francalanci, Franco,Marchi, Marcello,Cambiaghi, Stefano
, p. 1225 - 1229 (2007/10/02)
A new synthesis of the valuable penem antibiotics FCE 22101 and FCE 22891 which does not require the use of expensive protecting groups is reported.A mixed carbon-silicon protection of two hydroxy groups was used, followed by a selective enzymatic hydrolysis of the resulting 8-O-protected-2-carboxylic ester (18).Lipase from Chromobacterium viscosum and lipoprotein lipase from Pseudomonas sp. gave excellent results in both free or immobilized form.
