895153-67-0Relevant academic research and scientific papers
Optical resolution, stereoselective synthesis, and crystal structure of 9α-(3-azabicyclo[3,3,1]nonanyl)-2′cyclopentyl-2′-hydroxy- 2′-phenylacetate
Liu, Yan-Qing,Liu, He,Zhong, Bo-Hua,Deng, Yu-Lin,Liu, Ke-Liang
, p. 1403 - 1412 (2005)
9α-(3-Azabicyclo[3,3,1 ]nonanyl)-2′-cyclopentyl-2′- hydroxy-2′-phenylacetate (1) was synthesized and its enantiomers were obtained by the optical resolution of racemates with the chiral host N-p-toluenesulfonylglutamic acid. Optical pure 1 was also effect
SELECTIVE M4 RECEPTOR ANTAGONIST AND ITS MEDICAL USE
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Page/Page column 4, (2009/12/23)
The present invention provides a selective M4 receptor antagonist, levorotatory demethylated phencynonate or its nontoxic pharmaceutically acceptable salt, a pharmaceutical composition comprising this compound, and a use thereof in the manufacture of a medicament for the treatment of motion dysfunction, such as, tremor, rigor and the like caused by Parkinson's disease (PD). The structure of the compound is shown in Formula IIa:
