89518-83-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-nitrophenyl)imidazolidin-2-one is used as a building block for the synthesis of various drugs and pharmaceutical products due to its unique chemical structure and properties.
Used in Research and Development:
1-(4-nitrophenyl)imidazolidin-2-one is used as a compound in research and development for its potential biological and pharmacological properties, contributing to the discovery of new drugs and therapies.
Used in Organic Synthesis:
1-(4-nitrophenyl)imidazolidin-2-one is used as a versatile compound in organic synthesis, enabling the creation of a wide range of chemical products and intermediates.
Used in Medicinal Chemistry:
1-(4-nitrophenyl)imidazolidin-2-one is used in medicinal chemistry for its potential applications in the development of new medicines and therapeutic agents, given its unique structure and reactivity.

InChI:InChI=1/C9H9N3O3/c13-9-10-5-6-11(9)7-1-3-8(4-2-7)12(14)15/h1-4H,5-6H2,(H,10,13)

Upstream product

• 120-93-4 imidazolidone 
• 636-98-6 p-nitrobenzene iodide 
• 72866-60-5 1-chloroethyl isocyanate 
• 67052-23-7 N-(2-chloro-ethyl)-N'-(4-nitro-phenyl)-urea 
• 100-01-6 4-nitro-aniline 
• 100-28-7 4-Nitrophenyl isocyanate 
• 150847-03-3 1-(2-hydroxyethyl)-3-(4-nitrophenyl)urea 

Downstream Products

• 89518-99-0 1-(4-aminophenyl)-2-imidazolidinone 

Relevant academic research and scientific papers

Mild, convenient and versatile Cu-mediated synthesis of N-aryl-2-imidazolidinones

A mild, general, convenient and practical methodology for the selective copper-mediated mono N-arylation of unprotected 2-imidazolidinone was developed. Strong electron-donating groups and free hydroxy and amino groups on the aryl iodide substrates were well tolerated. The use of n-butanol as the solvent for the copper-catalysed mono-arylation of 2-imidazolidinone is unprecedented.

PYRAZINE DICARBOXAMIDES AND THE USE THEREOF

The invention relates to novel pyrazine dicarboxamides, methods for the use thereof, their use for treating and/or preventing diseases as well as to their use for producing medicaments for treating and/or preventing diseases, particularly thromboembolic disorders.

Investigation of the Mitsunobu reaction of N-(2-hydroxyethyl)-N'- phenyl-ureas

The Mitsunobu reaction of N-(2-hydroxyethyl)-ureas 1 using PPh3 and EtO2CN=NCO2Et led to the mixture of N- and O-alkylation products or a single isomer depending on the substrates.

ANTIHYPERTENSIVE 3-(UREIDOCYCLOHEXYLENEAMINO)PROPANE-1,2-DIOL DERIVATIVES

Certain 3-(ureidocyclohexyleneamino)propane-1,2-diol derivatives, such as the compounds of formula III below, represent novel and useful pharmaceutical agents, e.g. potent antihypertensive and cardioactive agents demonstrating both α-and β-adrenergic bloc