89524-12-9Relevant academic research and scientific papers
HUSY zeolite-promoted reactions of trifluoromethylated propargyl alcohols with arenes: Synthesis of CF3-indenes and DFT study of intermediate carbocations
Nursahedova, Selbi K.,Zerov, Aleksey V.,Boyarskaya, Irina A.,Grinenko, Elena V.,Nenajdenko, Valentine G.,Vasilyev, Aleksander V.
, p. 1215 - 1224 (2019)
The reaction of CF3-propargyl alcohols [ArCCCH(OH)CF3] with arenes under the action of acidic HUSY zeolite CBV-720 was investigated. It was found that the reaction at 100 °C for 1 h gave rise to 3-aryl-1-CF3-indenes in up
Catalytic Synthesis of Trifluoromethylated Allenes, Indenes, Chromenes, and Olefins from Propargylic Alcohols in HFIP
No?l, Florent,Vukovi?, Vuk D.,Yi, Jing,Richmond, Edward,Kravljanac, Pavle,Moran, Joseph
, p. 15926 - 15947 (2019/12/25)
A general method to access CF3-substituted allenes from propargylic alcohols under Lewis acid catalysis in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvent is described. By tuning the reaction time and temperature, the obtained allenes rearr
Ni-Catalyzed Defluorination for the Synthesis of gem-Difluoro-1,3-dienes and Their [4 + 2] Cycloaddition Reaction
Zhou, Minqi,Zhang, Jian,Zhang, Xing-Guo,Zhang, Xingang
supporting information, p. 671 - 674 (2019/01/21)
A nickel-catalyzed defluorination of α-trifluoromethylated allyl/propargyl carbonates using bis(pinacolato)diboron (B2pin2) as a reactant is described. The reaction proceeds under relatively mild reaction conditions, providing conjug
Lewis Acid-Catalyzed Rearrangement of Fluoroalkylated Propargylic Alcohols: An Alternative Approach to β-Fluoroalkyl-α,β-enones
Ramasamy, Manickavasakam,Lin, Hui-Chang,Kuo, Sheng-Chu,Hsieh, Min-Tsang
supporting information, p. 356 - 360 (2019/02/12)
A practical Lewis acid-catalyzed Meyer-Schuster rearrangement of fluoroalkylated propargylic alcohols, leading to a series of β-fluoroalkyl-α,β-enones, is developed. The methodology reported herein features moderate to high yields and high stereoselectivi
Gold-catalyzed synthesis of β-trifluoromethylated α,β-unsaturated ketones from CF3-substituted propargylic carboxylates and their reactivity in Diels-Alder reactions
Boreux, Arnaud,Lambion, Aubin,Campeau, Dominic,Sanita, Marina,Coronel, Ruben,Riant, Olivier,Gagosz, Fabien
supporting information, p. 5232 - 5239 (2018/06/01)
The synthesis of fluorinated synthetic intermediates has become a field of intense research in organic chemistry. In this article, we report the application of a gold-catalyzed rearrangement to the synthesis of β-trifluoromethylated α,β-unsaturated ketone
Method for synthesizing second-level trifluoromethyl propargyl alcohol
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Paragraph 0067; 0068; 0069, (2017/07/20)
The invention discloses a method for synthesizing second-level trifluoromethyl propargyl alcohol. The method comprises the following steps: enabling 2-iodo benzoic acid and sodium periodate to react so as to generate 1-(hydroxyl)-1,2-iodobenzoyl-3(1H)-ket
Synthesis of Trifluoromethyl-allenes by Gold-Catalyzed Rearrangement of Propargyl Benzyl Ethers
Boreux, Arnaud,Lonca, Geoffroy H.,Riant, Olivier,Gagosz, Fabien
supporting information, p. 5162 - 5165 (2016/10/14)
A new method for the synthesis of trifluoromethyl-allenes from easily accessible α-trifluoromethyl-propargyl benzyl ether derivatives following a gold-catalyzed intramolecular hydride transfer has been developed. Various di- and trisubstituted trifluoromethyl-allenes were obtained in good to excellent yields.
Kinetic resolution of fluorinated propargyl alcohols by lipase-catalyzed enantioselective transesterification
Ko, Sung-Jin,Lim, Jung Yun,Jeon, Nan Young,Won, Keehoon,Ha, Deok-Chan,Kim, Bum Tae,Lee, Hyuk
experimental part, p. 1109 - 1114 (2009/09/30)
In order to obtain optically active fluorinated propargyl alcohols, a lipase-catalyzed kinetic resolution has been carried out. The effect of lipase types, organic solvents, reaction temperature, and acyl donors was examined in the lipase-catalyzed transe
Fluoride-catalyzed nucleophilic perfluoroalkylations of acetylenic ketones or aldehydes
Manandhar, Sudha,Singh, Rajendra P.,Shreeve, Jean'ne M.
, p. 1296 - 1304 (2007/10/03)
Reactions of 4-phenylbut-3-yn-2-one (1a) and phenylpropynal (1b) with trimethyl(perfluoroalkyl)silanes (Me3SiRf) (Rf = CF3, C2F5, n-C6F13, n-C7F15/sub
Reduction of metal-stabilized α-CF3-carbenium ion complexes under mild conditions: Synthesis, structures, and reactivity
Gruselle, Michel,Malezieux, Bernard,Andres, Roman,Amouri, Hani,Vaissermann, Jacqueline,Melikyan, Gagik G.
, p. 359 - 368 (2007/10/03)
Complexed α-CF3 propargyl alcohols of the general formula [(M2L6)(μ-η2,η2-RC?CCH(CF3)(OH))] were prepared with M2L6 = CO2(CO)6, R = CH3/sub
