89524-12-9Relevant academic research and scientific papers
HUSY zeolite-promoted reactions of trifluoromethylated propargyl alcohols with arenes: Synthesis of CF3-indenes and DFT study of intermediate carbocations
Nursahedova, Selbi K.,Zerov, Aleksey V.,Boyarskaya, Irina A.,Grinenko, Elena V.,Nenajdenko, Valentine G.,Vasilyev, Aleksander V.
, p. 1215 - 1224 (2019)
The reaction of CF3-propargyl alcohols [ArCCCH(OH)CF3] with arenes under the action of acidic HUSY zeolite CBV-720 was investigated. It was found that the reaction at 100 °C for 1 h gave rise to 3-aryl-1-CF3-indenes in up
Ni-Catalyzed Defluorination for the Synthesis of gem-Difluoro-1,3-dienes and Their [4 + 2] Cycloaddition Reaction
Zhou, Minqi,Zhang, Jian,Zhang, Xing-Guo,Zhang, Xingang
supporting information, p. 671 - 674 (2019/01/21)
A nickel-catalyzed defluorination of α-trifluoromethylated allyl/propargyl carbonates using bis(pinacolato)diboron (B2pin2) as a reactant is described. The reaction proceeds under relatively mild reaction conditions, providing conjug
Lewis Acid-Catalyzed Rearrangement of Fluoroalkylated Propargylic Alcohols: An Alternative Approach to β-Fluoroalkyl-α,β-enones
Ramasamy, Manickavasakam,Lin, Hui-Chang,Kuo, Sheng-Chu,Hsieh, Min-Tsang
supporting information, p. 356 - 360 (2019/02/12)
A practical Lewis acid-catalyzed Meyer-Schuster rearrangement of fluoroalkylated propargylic alcohols, leading to a series of β-fluoroalkyl-α,β-enones, is developed. The methodology reported herein features moderate to high yields and high stereoselectivi
Catalytic Synthesis of Trifluoromethylated Allenes, Indenes, Chromenes, and Olefins from Propargylic Alcohols in HFIP
No?l, Florent,Vukovi?, Vuk D.,Yi, Jing,Richmond, Edward,Kravljanac, Pavle,Moran, Joseph
, p. 15926 - 15947 (2019/12/25)
A general method to access CF3-substituted allenes from propargylic alcohols under Lewis acid catalysis in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvent is described. By tuning the reaction time and temperature, the obtained allenes rearr
Gold-catalyzed synthesis of β-trifluoromethylated α,β-unsaturated ketones from CF3-substituted propargylic carboxylates and their reactivity in Diels-Alder reactions
Boreux, Arnaud,Lambion, Aubin,Campeau, Dominic,Sanita, Marina,Coronel, Ruben,Riant, Olivier,Gagosz, Fabien
supporting information, p. 5232 - 5239 (2018/06/01)
The synthesis of fluorinated synthetic intermediates has become a field of intense research in organic chemistry. In this article, we report the application of a gold-catalyzed rearrangement to the synthesis of β-trifluoromethylated α,β-unsaturated ketone
Method for synthesizing second-level trifluoromethyl propargyl alcohol
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Paragraph 0067; 0068; 0069, (2017/07/20)
The invention discloses a method for synthesizing second-level trifluoromethyl propargyl alcohol. The method comprises the following steps: enabling 2-iodo benzoic acid and sodium periodate to react so as to generate 1-(hydroxyl)-1,2-iodobenzoyl-3(1H)-ket
Synthesis of Trifluoromethyl-allenes by Gold-Catalyzed Rearrangement of Propargyl Benzyl Ethers
Boreux, Arnaud,Lonca, Geoffroy H.,Riant, Olivier,Gagosz, Fabien
supporting information, p. 5162 - 5165 (2016/10/14)
A new method for the synthesis of trifluoromethyl-allenes from easily accessible α-trifluoromethyl-propargyl benzyl ether derivatives following a gold-catalyzed intramolecular hydride transfer has been developed. Various di- and trisubstituted trifluoromethyl-allenes were obtained in good to excellent yields.
Kinetic resolution of fluorinated propargyl alcohols by lipase-catalyzed enantioselective transesterification
Ko, Sung-Jin,Lim, Jung Yun,Jeon, Nan Young,Won, Keehoon,Ha, Deok-Chan,Kim, Bum Tae,Lee, Hyuk
experimental part, p. 1109 - 1114 (2009/09/30)
In order to obtain optically active fluorinated propargyl alcohols, a lipase-catalyzed kinetic resolution has been carried out. The effect of lipase types, organic solvents, reaction temperature, and acyl donors was examined in the lipase-catalyzed transe
Fluoride-catalyzed nucleophilic perfluoroalkylations of acetylenic ketones or aldehydes
Manandhar, Sudha,Singh, Rajendra P.,Shreeve, Jean'ne M.
, p. 1296 - 1304 (2007/10/03)
Reactions of 4-phenylbut-3-yn-2-one (1a) and phenylpropynal (1b) with trimethyl(perfluoroalkyl)silanes (Me3SiRf) (Rf = CF3, C2F5, n-C6F13, n-C7F15/sub
Reduction of metal-stabilized α-CF3-carbenium ion complexes under mild conditions: Synthesis, structures, and reactivity
Gruselle, Michel,Malezieux, Bernard,Andres, Roman,Amouri, Hani,Vaissermann, Jacqueline,Melikyan, Gagik G.
, p. 359 - 368 (2007/10/03)
Complexed α-CF3 propargyl alcohols of the general formula [(M2L6)(μ-η2,η2-RC?CCH(CF3)(OH))] were prepared with M2L6 = CO2(CO)6, R = CH3/sub
