89539-54-8Relevant articles and documents
Design, synthesis and redox properties of two ferrocene-containing iron chelators
Moggia, Fabrice,Brisset, Hugues,Fages, Frédéric,Chaix, Carole,Mandrand, Bernard,Dias, Marylène,Levillain, Eric
, p. 3371 - 3374 (2006)
Two ferrocene-containing iron(III) chelators were synthesized from desferrioxamine B and kojic acid and their electronic absorption and electrochemical properties were studied in acetonitrile in the absence and presence of ferric ions. The results show a
Stilbene-like compound, and preparation method and application thereof
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Paragraph 0031; 0034; 0035; 0036; 0055; 0058; 0059; 0060, (2019/04/26)
The invention discloses a stilbene-like compound. The stilbene-like compound has a structure as shown in a general formula which is any one selected from the group consisting of formulas which are described in the specification. The invention also disclos
Synthesis and biological evaluation of deferiprone-resveratrol hybrids as antioxidants, Aβ1–42aggregation inhibitors and metal-chelating agents for Alzheimer's disease
Xu, Ping,Zhang, Minkui,Sheng, Rong,Ma, Yongmin
supporting information, p. 174 - 186 (2017/01/05)
A series of deferiprone-resveratrol hybrids have been designed and synthesized as multitarget-directed ligands (MTDLs) through merging the chelating moiety 3-hydroxypyridin-4-one into the structure of resveratrol, a natural antioxidant agent and β-amyloid peptide (Aβ) aggregation inhibitor. The in?vitro biological evaluation revealed that most of these newly synthesized compounds exhibited good inhibitory activity against self-induced Aβ1–42aggregation, excellent antioxidant activity and potent metal chelating capability. Compounds 3i and 4f were identified as the most promising MTDLs with triple functions, possessing micromolar IC50values for Aβ1–42aggregation inhibition, greater 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS?+) scavenging activity than Trolox and similar pFe(III) values to that of deferiprone.