895525-72-1

Usage

Uses

Used in Pharmaceutical Industry:
TFMA is used as a building block for the synthesis of various compounds in the pharmaceutical industry. Its unique structure and properties allow it to be a key component in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, TFMA is employed as a building block for the synthesis of different agrochemical compounds. Its versatility and stability make it a valuable asset in the development of new products for agricultural applications.
Used as a Protecting Group in Organic Synthesis:
TFMA is also used as a protecting group for amines in organic synthesis. This application takes advantage of its stability and non-hazardous nature, providing a reliable method for protecting amines during chemical reactions.

Upstream product

• 630117-94-1 N-[2-(trifluoromethyl)benzoyl] glycine 
• 312-94-7 2-trifluoromethylbenzoyl chloride 
• 360-64-5 2-(trifluoromethyl)benzamide 
• 433-97-6 2-trifluoromethylbenzoic acid 

Downstream Products

• 895525-76-5 dimethyl [3-chloro-5-(trifluoromethyl)pyridin-2-yl]({[2-(trifluoromethyl)benzoyl]amino}methyl)malonate 
• 895525-74-3 C₂₂H₁₉ClF₆N₂O₅ 

Relevant academic research and scientific papers

Synthesis method of fluopyram intermediate

The invention discloses a synthesis method of a fluopyram intermediate, and belongs to the field of organic synthesis of pesticides. The process comprises the following steps: by taking methanol amine as a starting raw material, carrying out esterification reaction on methanol amine and acetic anhydride in the presence of acetic acid to obtain methyl aminoacetate, and carrying out amidation reaction on methyl aminoacetate and o-trifluoromethyl benzoyl chloride to obtain N-acetoxymethyl-2-trifluoromethyl benzamide; and finally, carrying out a splicing reaction with diethyl 3-chloro-5-trifluoromethyl-2-pyridylmalonate, so as to obtain the 3-chloro-5-trifluoromethyl-2-pyridylethyl (diethyl ester)-2-trifluoromethyl benzamide. The method adopts a convergent synthesis route, has the characteristics of low raw material cost, high atom economy, high yield, simple process operation and the like, and is suitable for large-scale production.

Fluopyram and synthesis method thereof

The invention discloses fluopyram and a synthesis method thereof. The fluopyram comprises the following raw materials: trifluoromethylbenzoic acid, thionyl chloride, ammonia water, water, potassium carbonate, paraformaldehyde, formamide, acetic anhydride, 5-trifluoromethyl-2-dimethyl malonate--3-chloropyridine, sodium chloride and hydrochloric acid. The content of fluopyram obtained in the invention is 98% or more, and the total yield of fluopyram is 63% or more. The synthesis method of the invention does not use cyano groups with high activity, and the yield of aminolysis can reach 93%; the raw materials are simple to treat and high in utilization rate; waste gas, waste water and industrial residues are not produced; and the synthesis method is simple in process and easy to operate and implement.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

Acetamides and benzamides that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.