360-64-5Relevant articles and documents
Continuous process for production of CuCF3 via direct cupration of fluoroform
Mazloomi, Zahra,Bansode, Atul,Benavente, Pedro,Lishchynskyi, Anton,Urakawa, Atsushi,Grushin, Vladimir V.
, p. 1020 - 1026 (2014)
The first continuous flow process has been developed for the synthesis of a superior trifluoromethylating reagent, ligandless CuCF3, from fluoroform, by far the best CF3 source in terms of availability, cost, and atom economy. Optimization of the residence time and feed rates for CHF3 (gas), the cuprating reagent (premade from CuCl and t-BuOK in a 1:2 ratio) in DMF, and the stabilizer (Et3N· 3HF) at 23 °C and atmospheric pressure has allowed for the continuous production of CuCF3 in consistently high yields of up to 94%. The thus produced CuCF3 has been shown to be as highly efficient a trifluoromethylating agent as the one from the previously developed batch process.
Synthesis method 2 - trifluoromethyl benzamide
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Paragraph 0028; 0035; 0042-0043; 0055; 0062-0063, (2021/11/27)
The invention discloses a synthesis method of 2 -trifluoromethylbenzamide, which comprises the following steps of 2, 3 -dichloro-trifluorotoluene serving as a raw material and fluorinating. The preparation 2 -trifluoro -6 -cyano-trifluorotoluene is prepared by cyano substitution, 2 -fluoro -6 -cyanobenzotrifluoride is subjected to hydrogenation and dehydrochlorination, and 2 -trifluoromethylbenzamide is prepared by first hydrolyzing and dehydrochlorinating and dechlorinating. 2 - Trifluoromethylbenzamide is synthesized by simple reaction, and the method has the characteristics of cheap and easily available raw materials, no participation of the isomer 2 - fluorine -3 - chlorine - trifluorotoluene isomers in subsequent reaction and easy removal. In each reaction step, flammable and explosive, highly toxic or non-volatile agents commonly used in the existing synthetic method are not used, and harm to operating personnel and in the environment is avoided. , The total yield of the product reaches above 67%, and the purity is 97% or more.
Method for preparing amide compounds by using supported metal oxide catalytic material
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Paragraph 0134; 0135, (2020/06/05)
The invention relates to a catalyst for preparing amide compounds, and aims to provide a method for preparing amide compounds by using a supported metal oxide catalytic material. The method comprisesthe following steps: uniformly mixing a solvent, water, an organic nitrile compound and the catalytic material; performing a reaction at 50-180 DEG C for 0.5-48 h; and hydrating and converting the organic nitrile compound into the corresponding amide compounds through the catalytic hydration effect of the catalyst in the reaction process. Adsorption and activation of the catalytic material to water molecules can be effectively regulated by regulating metal components loaded on the catalytic material and a catalytic material carrier, so that important amide compounds in chemical and agricultural processes are efficiently prepared. The provided method for preparing the amide compounds is effect, and has the advantages of high atom utilization rate in the reaction process, low reaction temperature, no additional reaction assistant in the synthesis process, no generation of toxic or harmful byproducts after the reaction, and green and environment-friendly synthesis process.
