74857-16-2

Upstream product

• 59-31-4 2-hydroxyquinoline 
• 98-59-9 p-toluenesulfonyl chloride 
• 1613-37-2 Quinoline N-oxide 
• 6563-13-9 6-methoxyquinoline N-oxide 
• 59-31-4 2-quinolone 
• 30765-95-8 N-p-toluenesulfonyl-2-vinylaniline 
• 74857-00-4 2,2'-oxybis(4-chloroquinoline) 
• 881033-32-5 N-acryloyl-N-p-toluenesulfonyl-2-aminostyrene 

Downstream Products

• 1433415-94-1 (E)-2-(4-cinnamyl-2,3,5,6-tetrafluorophenyl)quinoline 
• 89562-59-4 2-(pentafluorophenyl)quinoline 
• 1315337-08-6 2-(2,3,5,6-tetrafluorophenyl)quinoline 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Catalyst-Controlled Selectivity in the Synthesis of C2- and C3-Sulfonate Esters from Quinoline N-Oxides and Aryl Sulfonyl Chlorides

The first example of the catalyst-controlled selective synthesis of C2- and C3-sulfonate-ester-substituted quinolines was developed by employing LaCl3 and chitosan@CuI catalysts, respectively. This protocol provides an expeditious route to an important class of quinoline derivatives frequently found in many biologically active compounds and features good practicality, high efficiency, and environmental friendliness. In addition, the easily recoverable chitosan@copper catalysts can be recycled five times without significant loss of catalytic performance.

Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium

Nucleophilic radiofluorination is an efficient synthetic route to many positron-emission tomography (PET) probes, but removal of water to activate the cyclotron-produced [18F]fluoride has to be performed prior to reaction, which significantly increases overall radiolabeling time and causes radioactivity loss. In this report, we demonstrate the possibility of 18F-radiofluorination in highly aqueous medium. The method utilizes titania nanoparticles, 1:1 (v/v) acetonitrile-thexyl alcohol solvent mixture, and tetra-n-butylammonium bicarbonate as a phase-transfer agent. Efficient radiolabeling is directly performed with aqueous [18F]fluoride without the need for a drying/azeotroping step to significantly reduce radiosynthesis time. High radiochemical purity of the target compound is also achieved. The substrate scope of the synthetic strategy is demonstrated with a range of aromatic, aliphatic, and cycloaliphatic tosylated precursors.

Pd-catalyzed direct cross-coupling of electron-deficient polyfluoroarenes with heteroaromatic tosylates

We report a Pd-catalyzed direct cross-coupling of electron-deficient polyfluoroarenes with heteroaromatic tosylates. The notable features of this reaction are its high reaction efficiency, excellent chemoselectivity, operational simplicity, and mild react

Preparation of N-sulfonyl-2-quinolinone using ring-closing metathesis(RCM)

An efficient method for the preparation of N-sulfonyl-2-quinolinone using ring-closing metathesis (RCM) is described.