89565-18-4Relevant articles and documents
Some Novel Sulfanilyl Derivatives
Cremlyn, R. J.,Swinbourne, F. S.,Batchelor, A.,Honeyman, R.,Nash, D.,et al.
, p. 1029 - 1043 (2007/10/02)
Benzoic acid anilide and p-chloro, m-nitro, together with the 2,4-, 2,5- and 3,4-dichloro derivatives, react with chlorosulfonic acid in 1:4 molar ratios to give the corresponding sulfanilyl chlorides.However, nicotinic acid and isonicotinic acid anilides react with chlorosulfonic acid in 1:6 molar ratios only for conversion into the sulfanilyl chlorides. 2,4-Dichlorophenoxyacetic acid anilide reacts with chlorosulfonic acid in 1:3 molar ratio to give the sulfanilyl chloride; this reaction when carried out in 1:7 molar ratios of the reactants affords the disulfonylchloride.The various sulfanilyl chlorides are reacted with amines, azide ion, and hydrazine to give a range of sulfonyl compounds.The compounds prepared have been subjected to preliminary biological screening.