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Upstream product

• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 2826-24-6 4-bromobenzylidenemalononitrile 
• 1122-91-4 4-bromo-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 109-77-3 malononitrile 
• 7803-57-8 hydrazine hydrate 
• 79785-97-0 hydrazine hydrate 
• 2033-24-1 cycl-isopropylidene malonate 
• 75-36-5 acetyl chloride 
• 105-45-3 acetoacetic acid methyl ester 
• 3206-39-1 3-methyl-2-pyrazoline-5-one 
• 89607-57-8 2-[(4-Bromo-phenyl)-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)-methyl]-malononitrile 
• 4344-87-0 3-hydroxy-5-methyl-1H-pyrazole 

Relevant academic research and scientific papers

Supported palladium oxide nanoparticles in Al-SBA-15 as an efficient and reusable catalyst for the synthesis of pyranopyrazole and benzylpyrazolyl coumarin derivatives via multicomponent reactions

An eco-friendly method for diversity-oriented synthesis of substituted dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been achieved via one-pot and multicomponent reaction in the presence of PdO/Al-SBA-15 as an efficient and rec

Synthesis, characterization and molecular docking of novel lonazolac analogues 3-(3-hydroxy-5-methyl-1H-pyrazol-4-yl)-3-arylpropanoic acid derivatives: Highly potential COX-1/COX-2, matrix metalloproteinase and protein denaturation inhibitors

The present article involves the design, synthesis, characterization, docking studies and anti-inflammatory activity of two new series of lonazolac analogue: 2a-p. Among the synthesized series, compounds 2b, 2c, 2e, 2f, 2 g, 2j, 2k, 2 m, 2n and 2o were screened for their in vitro COX-1 and COX-2 inhibition. All the screened targets exhibited excellent COX-1 and COX-2 inhibitory activity with low IC50 values compared to standard aspirin. Compound 2n showed excellent COX-1 inhibitory activity (IC50 = 127.00 μl/ml) while compound 2g was an excellent COX-2 inhibitor (IC50 = 5.83 μl/ml). Both 2n and 2g have superior selective index values of 19.53 and 29.41, respectively. The synthesized compounds 2a-2p, were screened against MMP-2 and MMP-9, anti-inflammatory activity comparable to that of tetracycline, as shown by gelatin zymography. Among the tested compounds, 2l showed excellent anti-inflammatory activity against both MMPs. On the other hand, the protein denaturation technique indicates that most of the molecules are beneficially active. A molecular docking study was performed to rationalize the anti-inflammatory activity of the synthesized compounds against standard celecoxib and aspirin, the results obtained are much better than the standard.

Catalyst-free UV365-assisted synthesis of pyran annulated heterocyclic scaffolds and evaluation of their antibacterial activities

A convenient and eco-friendly, one-pot synthetic protocol for pharmaceutically important pyran-based heterocyclic compounds is repeated herein. The reactions were carried out at room temperature in a water–ethanol solvent mixture under direct irradiation

Nano cobalt ferrite encapsulated-silica particles bearing melamine as an easily recyclable catalyst for the synthesis of dihydropyrano[2,3-c]pyrazoles under green conditions

In this research, it was displayed an efficient method for synthesis of 6-amino-2,4-dihydropyrano[2,3-c] pyrazol-5-carbonitrile derivatives by using CoFe2O4 silica supported bearing melamine as a magnetic nanocatalyst. This nanocompo

Magnetization of biochar nanoparticles as a novel support for fabrication of organo nickel as a selective, reusable and magnetic nanocatalyst in organic reactions

Catalyst species are an important class of materials in chemistry, industry, medicine and biotechnology. Also, waste recycling is an important process in green chemistry and economic efficiency. Therefore, in order to recycle waste, biochar nanoparticles were prepared from chicken manure. Then, the biochar nanoparticles were magnetized under a green and environmentally friendly method. Finally, the surface of the magnetic biochar nanoparticles was modified and further they were applied as a novel support for fabrication of nickel as a homoselective and reusable catalyst in organic reactions. The structure of this organic-inorganic catalyst has been characterized by N2adsorption-desorption isotherms, and the SEM, EDS, WDX, XRD, TGA, AAS, FT-IR and VSM techniques. This magnetically recyclable catalyst was used in the homoselective synthesis of tetrazole and pyranopyrazole derivatives. This catalyst can be reused several times without significant loss of its catalytic efficiency. The heterogeneity and stability of this nanocatalyst were studied by hot filtration and the AAS technique. Also, the reused catalyst was characterized by the SEM, EDS, AAS and BET techniques.

Concentrated solar radiation-assisted one-pot/multicomponent synthesis of pyranopyrazole derivatives under neat condition

Concentrated solar radiation (CSR)-assisted synthesis of pyranopyrazole derivatives under solvent and catalyst-free condition has been reported in the present protocol. One-pot multicomponent synthesis from aromatic/heteroaldehyde, ethyl acetoacetate, malononitrile, and hydrazine hydrate leads to the final desired compounds in a good yield. This operationally simple methodology has several advantages such as green and clean reaction profile, simple workup and purification procedures, extremely short reaction time, atom efficiency, and being economical. The current energy-efficient method saves almost 98% of energy as compared to the conventional method. Graphical abstract: [Figure not available: see fulltext.]

An approach to the synthesis and characterization of HMS/Pr-Rh-Zr as efficient catalyst for synthesis of tetrahydrobenzo[b]pyran and 1,4-dihydropyrano[2,3-c]pyrazole derivatives

The aim of present investigation is the synthesis of mesoporous catalyst based on hexagonal mesoporous silica. HMS support has exceptional properties such as easy synthesis, high surface area, large pore volume and wormhole pores. These distinctive charac

Magnetized melamine-modified polyacrylonitrile (PAN@melamine/Fe3O4) organometallic nanomaterial: Preparation, characterization, and application as a multifunctional catalyst in the synthesis of bioactive dihydropyrano [2,3-c]pyrazole

An efficient magnetic polymer-based nanomaterial was prepared in three main steps including synthesis of polyacrylonitrile (PAN), modification of PAN with melamine, and magnetization of the PAN@melamine compound by in situ construction of Fe3O

An inorganic–organic hybrid material based on a Keggin-type polyoxometalate@Dysprosium as an effective and green catalyst in the synthesis of 2-amino-4H-chromenes via multicomponent reactions

A novel inorganic–organic hybrid, [Dy4(PDA)4(H2O)11(SiMo12O40)]·7H2O denoted as (POM@Dy-PDA), based on a lanthanide cluster, a Keggin-type polyoxomolybdate, and PDA (1,10-phenant

Novel biocompatible core/shell Fe3O4?NFC?Co(ii) as a new catalyst in a multicomponent reaction: An efficient and sustainable methodology and novel reusable material for one-pot synthesis of 4: H -pyran and pyranopyrazole in aqueous media

Today, due to the developing need for inexpensive catalysts, recyclable magnetic nanocatalysts immobilized on polysaccharides possess many advantages over classical heterogeneous catalysts. However, cellulose has been an appealing material in catalysis sc