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Usage

Uses

Used in Pharmaceutical Industry:
3-AMINO-5-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER is used as a reactant in the reductive amination of carbonyl compounds with borohydride and borane reducing agents. This process is crucial in the synthesis of various pharmaceutical compounds, as it allows for the formation of new amines from carbonyl compounds, which are essential building blocks in the development of drugs and other bioactive molecules.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-AMINO-5-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER serves as an important intermediate for the production of various organic compounds. Its reactivity and functional groups make it a valuable component in the synthesis of complex molecules, including those with potential applications in materials science, agrochemicals, and other industries.
Used in Research and Development:
3-AMINO-5-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER is also utilized in research and development settings, where it can be employed to study the reactivity of different functional groups and explore novel synthetic pathways. Its unique structure and properties make it an interesting subject for academic research, potentially leading to new discoveries and innovations in the field of organic chemistry.

Upstream product

• 23842-82-2 2-amino-5-methoxybenzonitrile 

Downstream Products

• 1164548-54-2 ethyl (E)-3-(((dimethylamino)methylene)amino)-5-methoxy-1H-indole-2-carboxylate 
• 904508-37-8 C₂₇H₂₈N₄O₃S 
• 104961-44-6 3-(diethylamino)-5-methoxy-1-phenyl-1H-indole-2-carboxylic acid, ethyl ester 
• 104961-62-8 3-(diethylamino)-5-methoxy-1-phenyl-1H-indole-2-carboxylic acid 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization

A new class of inhibitors of tubulin polymerization based on the 2-alkoxycarbonyl-3-(3′,4′,5′-trimethoxyanilino)indole molecular skeleton was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization and cell cycle eff

PYRROLOPYRIMIDINE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE (MDR)

A compound which is a pyrrolopyrimidine of formula (I) wherein R1 is selected from H, Cl-C6 alkyl which is unsubstituted or substituted, (CH2)nAr1, (CH2)pNR4R5, halogen and (CH2)pX; R2 is CH2)pArl; R3 is selected from H, Cl -C6 alkyl which is unsubstituted or substituted, (CH2)pZ and (CH2)pArl; P is an unsaturated 5, 6, or 7 membered carbocyclic or heterocyclic ring which is unsubstituted or substituted; R4 and R5 which are the same or different are selected from H, Cl -C6 alkyl which is unsubstituted or substituted, (CH2)nC3-C10 cycloalkyl, (CH2)nAr1 , and (CH2)nOR6, or R4 and R5 together with the nitrogen atom to which they are attached, form a saturated five or six membered nitrogen containing heterocyclic ring which may contain one extra heteroatom selected from 0, N and S and which is unsubstituted or substituted; R6 is selected from H, Cl -C6 alkyl which is unsubstituted or substituted, C3-C10 cycloalkyl, (CH2)nOC1-C6alkyl which is unsubstituted or substituted, (CH2)nO(CH2)nAr1 , (CH2)nCO2C1-C6,alkyl which is unsubstituted or substituted and (CH2)nAr1; X is selected from CN, azide, (CH2)nNHSO2R6 and (CH2)nNHCOR6; Z is selected from CN, CO2R6 and CONR4R5; Ar1 is the same or different when more than one is present within a given substituent group and is an unsaturated C6-C10 membered carbocylic group or an unsaturated 5-11 membered heterocycle, either of which is unsubstituted or substituted; p is an integer of 1 to 6; n is the same or different when more than one is present within a given substituent group and is 0 or an integer of 1 to 6; with the proviso that the pyrrolepyrimidine compound of formula (I) is other than 1-(4-benzyl-piperazin-1-yl)-9H-2,4,9-triaza-fluorene; and the pharmaceutically acceptable salts thereof, have activity as inhibitors of MRP (multidrug resistant protein) and may thus be used to modulate multidrug resistance, for instance in potentiating the cytotoxicity of a chemotherapeutic agent.