89608-20-8Relevant academic research and scientific papers
SYNTHESIS, MOLECULAR STRUCTURE, AND ABSOLUTE CONFIGURATION OF 1-α-PHENYLETHYL-3-(2-CYANOETHYL)-4-PIPERIDONE
Grishina, G. V.,Abdulganeeva, S. A.,Potapov, V. M.,Ivanova, I. A.,Espenbetov, A. A.,et al.
, p. 1362 - 1368 (2007/10/02)
The Michael addition of acrylonitrile to the pyrrolidine enamine of 1-(S-α-phenylethyl)-4-piperidone proceeds with the formation of 1:1 mixture of 1-(S-α-phenylethyl)-3-(2-cyanoethyl)-4-piperidone diastereomers.A diastereomer isolated in pure form was sho
SYNTHESIS OF 3-SUBSTITUTED 4-PIPERIDONES
Grishina, G. V.,Potapov, V. M.,Abdulganeeva, S. A.,Ivanova, I. A.
, p. 1197 - 1201 (2007/10/02)
It has been shown that the addition of methyl acrylate and acrylonitrile to the pyrrolidine enamines of 1-methyl-, (1S)-α-phenylethyl-, (1S)-sec-butyl, 1,2-dimethyl, and 1,3-dimethyl-4-piperidone results in the formation of 3- or 5-substituted 4-piperidones, depending on the reaction conditions and the structure of the enamine.The formation of a pair of diastereomers of the 3-substituted 4-piperidones in a 1:1 ratio takes place when there is a chiral substituent on the nitrogen atom in the piperidone ring.
