89622-08-2Relevant academic research and scientific papers
REGIOSELECTIVE SYNTHESIS OF (+/-)-GABACULINE HYDROCHLORIDE
Frater, G.,Mueller, U.,Schoepfer, U.
, p. 281 - 284 (2007/10/02)
3-Cyclohexenecarboxylic acid (2) has been functionalized to the protected amino acid 5 in a novel reaction sequence, the crucial step being the acid catalysed cyclization of the γ,δ-unsaturated isocyanate 3 to the bicyclic lactam 4. 5 was converted into gabaculine hydrochloride (l HCl).
